{"id":5,"date":"2010-08-26T18:13:54","date_gmt":"2010-08-26T18:13:54","guid":{"rendered":"https:\/\/cellpathway.com\/?page_id=5"},"modified":"2026-07-30T17:40:41","modified_gmt":"2026-07-30T21:40:41","slug":"5-2","status":"publish","type":"page","link":"https:\/\/cellpathway.com\/?page_id=5","title":{"rendered":"Research"},"content":{"rendered":"<p><!-- cellpathway-research-visuals-v1 --><\/p>\n<style>\n#post-5>h2.title{display:none!important}\n.cp-research{--navy:#2b2626;--blue:#7a4f4f;--cyan:#b78f8f;--gold:#9c6f35;--ink:#000;--mist:#f6eeee;--paper:#fff;max-width:1100px;margin:0 auto;color:#000}\n.cp-research *{box-sizing:border-box}\n.cp-research-hero{position:relative;overflow:hidden;margin:0 0 2rem;padding:clamp(2rem,5vw,4.25rem);padding-bottom:clamp(1.5rem,3vw,2.25rem);border:1px solid #eadcdc;border-radius:14px;background:linear-gradient(135deg,#fff 0%,#fbf7f7 58%,#f2e7e7 100%);color:#303030;box-shadow:0 10px 28px 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svg{width:16px;height:16px}}\n.cp-section-figure{position:relative!important;display:flow-root!important;clear:both!important;float:none!important;box-sizing:border-box!important;width:100%!important;max-width:100%!important;height:auto!important;margin:1rem 0 1.65rem!important;padding:1rem!important;overflow:visible!important;border:1px solid #e2d2d2;border-radius:12px;background:#fff;box-shadow:0 5px 16px rgba(88,55,55,.07)}\n.cp-section-figure-link{position:relative!important;display:block!important;clear:both!important;float:none!important;box-sizing:border-box!important;width:100%!important;max-width:100%!important;height:auto!important;margin:0!important;text-align:center;overflow:visible!important}\n.cp-section-figure-image,.cp-research .cp-section-figure img{position:relative!important;inset:auto!important;display:block!important;clear:both!important;float:none!important;box-sizing:border-box!important;width:100%!important;max-width:100%!important;height:auto!important;max-height:none!important;min-height:0!important;margin:0 auto!important;padding:0!important;object-fit:contain!important;transform:none!important}\n.cp-section-figure figcaption{position:relative!important;inset:auto!important;display:block!important;clear:both!important;float:none!important;box-sizing:border-box!important;width:100%!important;height:auto!important;margin:.8rem 0 0!important;padding:0 .2rem!important;color:#000;font-size:.78rem;line-height:1.5;transform:none!important}\n.cp-section-figure figcaption strong{display:block;margin-bottom:.15rem;font-size:.88rem}\n.cp-section-figure figcaption a{color:#6d4848;text-decoration:underline;text-underline-offset:2px}\n.cp-section-figure figcaption a:hover,.cp-section-figure figcaption a:focus{color:#000}\n.cp-section-figure + p{position:relative;clear:both!important;margin-top:0!important}\n@media(max-width:640px){.cp-section-figure{padding:.6rem!important;margin:.8rem 0 1.35rem!important}.cp-section-figure figcaption{font-size:.74rem}}\n<\/style>\n<div class=\"cp-research\">\n<section class=\"cp-research-hero\" aria-labelledby=\"cp-research-title\">\n<p class=\"cp-eyebrow\">Salomon Laboratory \u00b7 Brown University<\/p>\n<h2 id=\"cp-research-title\">Decoding cellular signals to advance human health<\/h2>\n<p>We combine quantitative phosphoproteomics, immune-cell biology, and computational analysis to reveal how signaling networks control T cells, cancer, and disease.<\/p>\n<div class=\"cp-pathway\" aria-label=\"Research workflow: receptor to signaling network to mass spectrometry to insight\">\n      <span class=\"cp-node\">Receptor<\/span><span class=\"cp-arrow\" aria-hidden=\"true\"><\/span><br \/>\n      <span class=\"cp-node\">Network<\/span><span class=\"cp-arrow\" aria-hidden=\"true\"><\/span><br \/>\n      <span class=\"cp-node\">LC\u2013MS<\/span><span class=\"cp-arrow\" aria-hidden=\"true\"><\/span><br \/>\n      <span class=\"cp-node\">Insight<\/span>\n    <\/div>\n<\/section>\n<nav class=\"cp-research-map\" aria-label=\"Research areas\">\n    <a href=\"#car-t-signaling\"><span class=\"cp-map-icon\" aria-hidden=\"true\"><svg viewBox=\"0 0 48 48\" focusable=\"false\"><circle cx=\"15\" cy=\"24\" r=\"9\"\/><path d=\"M9 18l-4-4m4 16l-4 4m16-16l4-4m-4 16l4 4\"\/><circle cx=\"35\" cy=\"24\" r=\"7\"\/><path d=\"M24 24h4m7-11v4m0 14v4m-11-11l5-3m-5 3l5 3\"\/><\/svg><\/span><span class=\"cp-map-label\">CAR T signaling<\/span><\/a><br \/>\n    <a href=\"#tcr-networks\"><span class=\"cp-map-icon\" aria-hidden=\"true\"><svg viewBox=\"0 0 48 48\" focusable=\"false\"><path d=\"M4 20h40M4 24h40\"\/><path d=\"M18 5l6 8 6-8M24 13v17\"\/><path d=\"M18 30h12M20 30l-5 7m13-7l5 7\"\/><circle cx=\"15\" cy=\"39\" r=\"3\"\/><circle cx=\"33\" cy=\"39\" r=\"3\"\/><circle cx=\"24\" cy=\"43\" r=\"3\"\/><path d=\"M18 40l3 2m9-2l-3 2\"\/><\/svg><\/span><span class=\"cp-map-label\">TCR networks<\/span><\/a><br \/>\n    <a href=\"#phosphoproteomics\"><span class=\"cp-map-icon\" aria-hidden=\"true\"><svg viewBox=\"0 0 48 48\" focusable=\"false\"><path d=\"M5 38h38M8 35V25m6 10V13m6 22V29m6 6V8m6 27V20m6 15V16\"\/><circle cx=\"14\" cy=\"8\" r=\"3\"\/><circle cx=\"32\" cy=\"10\" r=\"3\"\/><path d=\"M17 9l12 1\"\/><\/svg><\/span><span class=\"cp-map-label\">Phosphoproteomics<\/span><\/a><br \/>\n    <a href=\"#computational-platforms\"><span class=\"cp-map-icon\" aria-hidden=\"true\"><svg viewBox=\"0 0 48 48\" focusable=\"false\"><rect x=\"5\" y=\"7\" width=\"38\" height=\"28\" rx=\"3\"\/><path d=\"M16 42h16M24 35v7\"\/><circle cx=\"14\" cy=\"20\" r=\"3\"\/><circle cx=\"25\" cy=\"14\" r=\"3\"\/><circle cx=\"34\" cy=\"25\" r=\"3\"\/><circle cx=\"22\" cy=\"27\" r=\"3\"\/><path d=\"M17 18l5-2m5 0l5 7m-13 3l-3-4m9 4l6-1\"\/><\/svg><\/span><span class=\"cp-map-label\">Computational platforms<\/span><\/a><br \/>\n    <a href=\"#human-disease\"><span class=\"cp-map-icon\" aria-hidden=\"true\"><svg viewBox=\"0 0 48 48\" focusable=\"false\"><path d=\"M24 43c-3-5-15-11-15-23 0-7 4-12 10-12 3 0 5 2 5 5 0-3 2-5 5-5 6 0 10 5 10 12 0 12-12 18-15 23z\"\/><path d=\"M12 25h7l3-7 5 14 3-7h6\"\/><\/svg><\/span><span class=\"cp-map-label\">Human disease<\/span><\/a><br \/>\n  <\/nav>\n<div class=\"cp-research-content\">\n<h3 id=\"research-introduction\">Introduction<\/h3>\n<p class=\"p1\">Our lab research centers on cellular signaling and the use of advanced quantitative proteomics to uncover the molecular mechanisms underlying immune cell function and cancer. Over the past decade, our laboratory has developed and applied cutting-edge mass spectrometry workflows to analyze complex phosphorylation networks, enabling precise identification of regulatory pathways. Our current work focuses on T cell receptor and CAR T cell signaling, with particular emphasis on defining phosphorylation-dependent networks that control T cell activation, feedback regulation, and pathway crosstalk, and on determining how CAR design reshapes signaling in both effector and target cells. By integrating biochemical, molecular, and computational approaches with state-of-the-art LC-MS phosphoproteomic analysis, we aim to identify signaling mechanisms that govern immune responses and influence the efficacy, specificity, and safety of immune-based therapies for cancer and other human diseases.<\/p>\n<h3 id=\"car-t-signaling\">Proteomic dissection of CAR T-cell design, signaling networks, and target-cell responses<\/h3>\n<figure class=\"cp-section-figure\"><a class=\"cp-section-figure-link\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12684228\/\" target=\"_blank\" rel=\"noopener noreferrer\"><img width=\"1600\" height=\"1870\" src=\"https:\/\/cellpathway.com\/wp-content\/uploads\/2026\/07\/scisignal-car-panels-1f-3b-3g-1.jpg\" class=\"cp-section-figure-image\" alt=\"CAR T phosphotyrosine proteomics workflow, target-cell volcano plots, and regulated CSF1R-CAR signaling sites from Science Signaling Figures 1F, 3B, and 3G\" loading=\"lazy\" decoding=\"async\" sizes=\"auto, (max-width: 1100px) calc(100vw - 3rem), 1040px\" srcset=\"https:\/\/cellpathway.com\/wp-content\/uploads\/2026\/07\/scisignal-car-panels-1f-3b-3g-1.jpg 1600w, https:\/\/cellpathway.com\/wp-content\/uploads\/2026\/07\/scisignal-car-panels-1f-3b-3g-1-257x300.jpg 257w, https:\/\/cellpathway.com\/wp-content\/uploads\/2026\/07\/scisignal-car-panels-1f-3b-3g-1-876x1024.jpg 876w, https:\/\/cellpathway.com\/wp-content\/uploads\/2026\/07\/scisignal-car-panels-1f-3b-3g-1-768x898.jpg 768w, https:\/\/cellpathway.com\/wp-content\/uploads\/2026\/07\/scisignal-car-panels-1f-3b-3g-1-1314x1536.jpg 1314w\" \/><\/a><figcaption><strong>Bidirectional phosphotyrosine proteomics of CAR T and target-cell signaling.<\/strong> <span>Science Signaling Figure 1F shows the coculture proteomics workflow; Figure 3B maps target-cell phosphorylation responses; and Figure 3G highlights regulated signaling sites downstream of CSF1R-CAR activation. Source: <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12684228\/\" target=\"_blank\" rel=\"noopener noreferrer\">Callahan et al., Science Signaling (2025), Figures 1F, 3B, and 3G<\/a>.<\/span><\/figcaption><\/figure>\n<p class=\"p1\">We use state-of-the-art quantitative phosphoproteomics to understand how CAR T cells alter signaling in both effector and target cells. By developing bidirectional coculture workflows that assign phosphorylation events to their cell of origin, we have mapped CAR-specific signaling networks, uncovered suppression of target-cell pathways in some settings, and shown that certain CAR designs can induce pro-growth signaling in tumor targets. This work provides critical mechanistic insight into how CAR structure shapes therapeutic responses and helps identify strategies to engineer safer, more effective cancer immunotherapies.<\/p>\n<div style=\"width: 100%; background: #eeeeee; padding: 5px 0 5px 5px;\">\n<h4>Our publications in this Area<\/h4>\n<ol start=\"1\">\n<li>\n<p class=\"p1\">A. Callahan, R. Puterbaugh, T. Ro, X. Zhang, X. Su, A. Salomon. (2026). \u201cPhosphoproteomic analysis of successive Jurkat CD19-CAR generations reveals TCR\u03b6-driven signalling.\u201d <i>Cell. Signal.<\/i>, 138:112204. doi:10.1016\/j.cellsig.2025.112204. <span class=\"cp-paper-links\" aria-label=\"Publication links\"><a class=\"cp-source-link cp-source-pmc\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12664688\/\" aria-label=\"Read full text in PubMed Central\" title=\"Read full text in PubMed Central\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M8 9h12c3 0 5 2 5 5v25c0-3-2-5-5-5H8z\"\/><path d=\"M40 9H28c-2 0-3 2-3 5v25c0-3 2-5 5-5h10z\"\/><path d=\"M12 16h8m-8 6h8\"\/><\/svg><span>PMC<\/span><\/a><a class=\"cp-source-link cp-source-journal\" href=\"https:\/\/doi.org\/10.1016\/j.cellsig.2025.112204\" aria-label=\"Open the journal article\" title=\"Open the journal article\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M9 7h20l10 10v24H9z\"\/><path d=\"M29 7v10h10M15 25h18m-18 6h18\"\/><path d=\"M30 22l8-8m-6 0h6v6\"\/><\/svg><span>JOURNAL<\/span><\/a><a class=\"cp-source-link cp-source-pubmed\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41177417\/\" aria-label=\"View the PubMed abstract\" title=\"View the PubMed abstract\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><rect x=\"7\" y=\"8\" width=\"34\" height=\"32\" rx=\"3\"\/><path d=\"M13 16h22M13 23h22M13 30h14\"\/><circle cx=\"34\" cy=\"32\" r=\"4\"\/><\/svg><span>PUBMED<\/span><\/a><\/span><\/p>\n<\/li>\n<li>\n<p class=\"p1\">A. Callahan, S.S. Trychanh, T. Ro, A. Mojumdar, A.R. Salomon*. (2026). \u201cPhosphotyrosine proteomics reveals novel Zap70 and Itk pathway targets downstream of TCR and CAR in Jurkat T cells.\u201d <i>Sci. Rep.<\/i>, in press. doi:10.1038\/s41598-026-47234-x. (*corresponding author). <span class=\"cp-paper-links\" aria-label=\"Publication links\"><a class=\"cp-source-link cp-source-pmc\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC13216648\/\" aria-label=\"Read full text in PubMed Central\" title=\"Read full text in PubMed Central\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M8 9h12c3 0 5 2 5 5v25c0-3-2-5-5-5H8z\"\/><path d=\"M40 9H28c-2 0-3 2-3 5v25c0-3 2-5 5-5h10z\"\/><path d=\"M12 16h8m-8 6h8\"\/><\/svg><span>PMC<\/span><\/a><a class=\"cp-source-link cp-source-journal\" href=\"https:\/\/doi.org\/10.1038\/s41598-026-47234-x\" aria-label=\"Open the journal article\" title=\"Open the journal article\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M9 7h20l10 10v24H9z\"\/><path d=\"M29 7v10h10M15 25h18m-18 6h18\"\/><path d=\"M30 22l8-8m-6 0h6v6\"\/><\/svg><span>JOURNAL<\/span><\/a><a class=\"cp-source-link cp-source-pubmed\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41942704\/\" aria-label=\"View the PubMed abstract\" title=\"View the PubMed abstract\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><rect x=\"7\" y=\"8\" width=\"34\" height=\"32\" rx=\"3\"\/><path d=\"M13 16h22M13 23h22M13 30h14\"\/><circle cx=\"34\" cy=\"32\" r=\"4\"\/><\/svg><span>PUBMED<\/span><\/a><\/span><\/p>\n<\/li>\n<li>\n<p class=\"p1\">A. Callahan, X. Zhang, A. Wang, A. Mojumdar, L. Zeng, X. Su*, A. Salomon*. (2025). \u201cCSF1R-CAR T cells induce CSF1R signaling and can promote cancer cell growth.\u201d <i>Sci. Signal.<\/i>, 18(913):eadv4112. doi:10.1126\/scisignal.adv4112. (*corresponding authors). <span class=\"cp-paper-links\" aria-label=\"Publication links\"><a class=\"cp-source-link cp-source-pmc\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12684228\/\" aria-label=\"Read full text in PubMed Central\" title=\"Read full text in PubMed Central\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M8 9h12c3 0 5 2 5 5v25c0-3-2-5-5-5H8z\"\/><path d=\"M40 9H28c-2 0-3 2-3 5v25c0-3 2-5 5-5h10z\"\/><path d=\"M12 16h8m-8 6h8\"\/><\/svg><span>PMC<\/span><\/a><a class=\"cp-source-link cp-source-journal\" href=\"https:\/\/doi.org\/10.1126\/scisignal.adv4112\" aria-label=\"Open the journal article\" title=\"Open the journal article\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M9 7h20l10 10v24H9z\"\/><path d=\"M29 7v10h10M15 25h18m-18 6h18\"\/><path d=\"M30 22l8-8m-6 0h6v6\"\/><\/svg><span>JOURNAL<\/span><\/a><a class=\"cp-source-link cp-source-pubmed\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41218104\/\" aria-label=\"View the PubMed abstract\" title=\"View the PubMed abstract\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><rect x=\"7\" y=\"8\" width=\"34\" height=\"32\" rx=\"3\"\/><path d=\"M13 16h22M13 23h22M13 30h14\"\/><circle cx=\"34\" cy=\"32\" r=\"4\"\/><\/svg><span>PUBMED<\/span><\/a><\/span><\/p>\n<\/li>\n<li>\n<p class=\"p1\">A. Griffith, K. Callahan, N. King, Q. Xiao, X. Su, A. Salomon. (2022). \u201cSILAC phosphoproteomics reveals unique signaling circuits in CAR-T cells and the inhibition of B cell-activating phosphorylation in target cells.\u201d <i>J. Proteome Res.<\/i>, 21(2):395\u2013409. <span class=\"cp-paper-links\" aria-label=\"Publication links\"><a class=\"cp-source-link cp-source-pmc\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8830406\/\" aria-label=\"Read full text in PubMed Central\" title=\"Read full text in PubMed Central\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M8 9h12c3 0 5 2 5 5v25c0-3-2-5-5-5H8z\"\/><path d=\"M40 9H28c-2 0-3 2-3 5v25c0-3 2-5 5-5h10z\"\/><path d=\"M12 16h8m-8 6h8\"\/><\/svg><span>PMC<\/span><\/a><a class=\"cp-source-link cp-source-journal\" href=\"https:\/\/doi.org\/10.1021\/acs.jproteome.1c00735\" aria-label=\"Open the journal article\" title=\"Open the journal article\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M9 7h20l10 10v24H9z\"\/><path d=\"M29 7v10h10M15 25h18m-18 6h18\"\/><path d=\"M30 22l8-8m-6 0h6v6\"\/><\/svg><span>JOURNAL<\/span><\/a><a class=\"cp-source-link cp-source-pubmed\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35014847\/\" aria-label=\"View the PubMed abstract\" title=\"View the PubMed abstract\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><rect x=\"7\" y=\"8\" width=\"34\" height=\"32\" rx=\"3\"\/><path d=\"M13 16h22M13 23h22M13 30h14\"\/><circle cx=\"34\" cy=\"32\" r=\"4\"\/><\/svg><span>PUBMED<\/span><\/a><\/span><\/p>\n<\/li>\n<\/ol>\n<\/div>\n<h3 id=\"tcr-networks\" class=\"p1\"><b>Quantitative Dissection of Proximal TCR Signaling Networks<\/b><\/h3>\n<figure class=\"cp-section-figure\"><a class=\"cp-section-figure-link\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12311025\/\" target=\"_blank\" rel=\"noopener noreferrer\"><img width=\"1835\" height=\"2362\" src=\"https:\/\/cellpathway.com\/wp-content\/uploads\/2026\/07\/cellpathway-tcptp-tcr-hires.png\" class=\"cp-section-figure-image\" alt=\"Models comparing TCPTP, PTPN22, and SHP1 effects on phosphotyrosine abundance, TCR signaling strength, and pathway regulation\" loading=\"lazy\" decoding=\"async\" srcset=\"https:\/\/cellpathway.com\/wp-content\/uploads\/2026\/07\/cellpathway-tcptp-tcr-hires.png 1835w, https:\/\/cellpathway.com\/wp-content\/uploads\/2026\/07\/cellpathway-tcptp-tcr-hires-233x300.png 233w, https:\/\/cellpathway.com\/wp-content\/uploads\/2026\/07\/cellpathway-tcptp-tcr-hires-796x1024.png 796w, https:\/\/cellpathway.com\/wp-content\/uploads\/2026\/07\/cellpathway-tcptp-tcr-hires-768x989.png 768w, https:\/\/cellpathway.com\/wp-content\/uploads\/2026\/07\/cellpathway-tcptp-tcr-hires-1193x1536.png 1193w, https:\/\/cellpathway.com\/wp-content\/uploads\/2026\/07\/cellpathway-tcptp-tcr-hires-1591x2048.png 1591w\" sizes=\"auto, (max-width: 1835px) 100vw, 1835px\" \/><\/a><figcaption><strong>Model comparing the distinct effects of TCPTP, PTPN22, and SHP1 on phosphotyrosine abundance, TCR signal strength, and pathway regulation.<\/strong> <span>Source: <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12311025\/\" target=\"_blank\" rel=\"noopener noreferrer\">Callahan et al., Scientific Reports (2025), Figure 7<\/a> \u00b7 <a href=\"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/\" target=\"_blank\" rel=\"license noopener noreferrer\">CC BY-NC-ND 4.0<\/a>.<\/span><\/figcaption><\/figure>\n<p class=\"p1\">Our laboratory has helped define how proximal T cell receptor (TCR) signaling is organized through feedback control, pathway crosstalk, and phosphotyrosine network regulation. Using quantitative phosphoproteomics and complementary biochemical approaches, we have identified new signaling proteins and phosphosites, revealed dynamic feedback mechanisms involving SLP-76, ZAP-70, Vav1, PLC-\u03b31, ERK, and key phosphatases, and clarified how these pathways shape T cell activation thresholds and signaling output. This work has advanced the field from static pathway models toward a systems-level understanding of how T cells balance sensitivity with control. Because these regulatory mechanisms influence immune activation in cancer, infection, and autoimmune disease, they provide an important foundation for understanding immune dysfunction and for developing strategies to therapeutically modulate T cell responses.<\/p>\n<div style=\"width: 100%; background: #eeeeee; padding: 5px 0 5px 5px;\">\n<h4>Our publications in this Area<\/h4>\n<ol>\n<li style=\"list-style-type: none;\">\n<ol style=\"list-style-type: decimal; padding-left: 20px;\">\n<li>\n<p class=\"p1\">A. Callahan, A. Mojumdar, M. Hu, A. Wang, A. Griffith, N. Huang, X. Chua, N. Mroz, R. Puterbaugh, S. Reilly, A. Salomon. (2025). \u201cThe phosphatases TCPTP, PTPN22, and SHP1 play unique roles in T cell phosphotyrosine maintenance and feedback regulation of the TCR.\u201d <i>Sci. Rep.<\/i>, 15:27747. <span class=\"cp-paper-links\" aria-label=\"Publication links\"><a class=\"cp-source-link cp-source-pmc\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12311025\/\" aria-label=\"Read full text in PubMed Central\" title=\"Read full text in PubMed Central\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M8 9h12c3 0 5 2 5 5v25c0-3-2-5-5-5H8z\"\/><path d=\"M40 9H28c-2 0-3 2-3 5v25c0-3 2-5 5-5h10z\"\/><path d=\"M12 16h8m-8 6h8\"\/><\/svg><span>PMC<\/span><\/a><a class=\"cp-source-link cp-source-journal\" href=\"https:\/\/doi.org\/10.1038\/s41598-025-12951-2\" aria-label=\"Open the journal article\" title=\"Open the journal article\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M9 7h20l10 10v24H9z\"\/><path d=\"M29 7v10h10M15 25h18m-18 6h18\"\/><path d=\"M30 22l8-8m-6 0h6v6\"\/><\/svg><span>JOURNAL<\/span><\/a><a class=\"cp-source-link cp-source-pubmed\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40739316\/\" aria-label=\"View the PubMed abstract\" title=\"View the PubMed abstract\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><rect x=\"7\" y=\"8\" width=\"34\" height=\"32\" rx=\"3\"\/><path d=\"M13 16h22M13 23h22M13 30h14\"\/><circle cx=\"34\" cy=\"32\" r=\"4\"\/><\/svg><span>PUBMED<\/span><\/a><\/span><\/p>\n<\/li>\n<li>\n<p class=\"p1\">X. Chua, A. Salomon. (2021). \u201cOvalbumin antigen-specific activation of human T cell receptor closely resembles soluble antibody stimulation as revealed by BOOST phosphotyrosine proteomics.\u201d <i>J. Proteome Res.<\/i>, 20(6):3330\u20133344. <span class=\"cp-paper-links\" aria-label=\"Publication links\"><a class=\"cp-source-link cp-source-pmc\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8626127\/\" aria-label=\"Read full text in PubMed Central\" title=\"Read full text in PubMed Central\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M8 9h12c3 0 5 2 5 5v25c0-3-2-5-5-5H8z\"\/><path d=\"M40 9H28c-2 0-3 2-3 5v25c0-3 2-5 5-5h10z\"\/><path d=\"M12 16h8m-8 6h8\"\/><\/svg><span>PMC<\/span><\/a><a class=\"cp-source-link cp-source-journal\" href=\"https:\/\/doi.org\/10.1021\/acs.jproteome.1c00239\" aria-label=\"Open the journal article\" title=\"Open the journal article\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M9 7h20l10 10v24H9z\"\/><path d=\"M29 7v10h10M15 25h18m-18 6h18\"\/><path d=\"M30 22l8-8m-6 0h6v6\"\/><\/svg><span>JOURNAL<\/span><\/a><a class=\"cp-source-link cp-source-pubmed\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34018748\/\" aria-label=\"View the PubMed abstract\" title=\"View the PubMed abstract\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><rect x=\"7\" y=\"8\" width=\"34\" height=\"32\" rx=\"3\"\/><path d=\"M13 16h22M13 23h22M13 30h14\"\/><circle cx=\"34\" cy=\"32\" r=\"4\"\/><\/svg><span>PUBMED<\/span><\/a><\/span><\/p>\n<\/li>\n<li>\n<p class=\"p1\">X. Chua, T. Aballo, W. Elnemer, M. Tran, A. Salomon. (2021). \u201cQuantitative interactomics of Lck-TurboID in living human T cells unveils T cell receptor stimulation-induced proximal Lck interactors.\u201d <i>J. Proteome Res.<\/i>, 20(1):715\u2013726. <span class=\"cp-paper-links\" aria-label=\"Publication links\"><a class=\"cp-source-link cp-source-pmc\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7962135\/\" aria-label=\"Read full text in PubMed Central\" title=\"Read full text in PubMed Central\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M8 9h12c3 0 5 2 5 5v25c0-3-2-5-5-5H8z\"\/><path d=\"M40 9H28c-2 0-3 2-3 5v25c0-3 2-5 5-5h10z\"\/><path d=\"M12 16h8m-8 6h8\"\/><\/svg><span>PMC<\/span><\/a><a class=\"cp-source-link cp-source-journal\" href=\"https:\/\/doi.org\/10.1021\/acs.jproteome.0c00616\" aria-label=\"Open the journal article\" title=\"Open the journal article\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M9 7h20l10 10v24H9z\"\/><path d=\"M29 7v10h10M15 25h18m-18 6h18\"\/><path d=\"M30 22l8-8m-6 0h6v6\"\/><\/svg><span>JOURNAL<\/span><\/a><a class=\"cp-source-link cp-source-pubmed\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33185455\/\" aria-label=\"View the PubMed abstract\" title=\"View the PubMed abstract\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><rect x=\"7\" y=\"8\" width=\"34\" height=\"32\" rx=\"3\"\/><path d=\"M13 16h22M13 23h22M13 30h14\"\/><circle cx=\"34\" cy=\"32\" r=\"4\"\/><\/svg><span>PUBMED<\/span><\/a><\/span><\/p>\n<\/li>\n<li>\n<p class=\"p1\">W. Lo, N.H. Shah, N. Ahsan, V. Horkova, O. Stepanek, A.R. Salomon, J. Kuriyan, A. Weiss. (2018). \u201cLck promotes Zap70-dependent LAT phosphorylation by bridging Zap70 to LAT.\u201d <i>Nat. Immunol.<\/i>, 19(7):733\u2013741. <span class=\"cp-paper-links\" aria-label=\"Publication links\"><a class=\"cp-source-link cp-source-pmc\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6202249\/\" aria-label=\"Read full text in PubMed Central\" title=\"Read full text in PubMed Central\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M8 9h12c3 0 5 2 5 5v25c0-3-2-5-5-5H8z\"\/><path d=\"M40 9H28c-2 0-3 2-3 5v25c0-3 2-5 5-5h10z\"\/><path d=\"M12 16h8m-8 6h8\"\/><\/svg><span>PMC<\/span><\/a><a class=\"cp-source-link cp-source-journal\" href=\"https:\/\/doi.org\/10.1038\/s41590-018-0131-1\" aria-label=\"Open the journal article\" title=\"Open the journal article\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M9 7h20l10 10v24H9z\"\/><path d=\"M29 7v10h10M15 25h18m-18 6h18\"\/><path d=\"M30 22l8-8m-6 0h6v6\"\/><\/svg><span>JOURNAL<\/span><\/a><a class=\"cp-source-link cp-source-pubmed\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29915297\/\" aria-label=\"View the PubMed abstract\" title=\"View the PubMed abstract\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><rect x=\"7\" y=\"8\" width=\"34\" height=\"32\" rx=\"3\"\/><path d=\"M13 16h22M13 23h22M13 30h14\"\/><circle cx=\"34\" cy=\"32\" r=\"4\"\/><\/svg><span>PUBMED<\/span><\/a><\/span><\/p>\n<\/li>\n<li>\n<p class=\"p1\">J. Belmont, T. Gu, A. Mudd, A.R. Salomon. (2017). \u201cA PLC-\u03b31 feedback pathway regulates Lck substrate phosphorylation at the T-cell receptor and SLP-76 complex.\u201d <i>J. Proteome Res.<\/i>, 16(8):2729\u20132742. <span class=\"cp-paper-links\" aria-label=\"Publication links\"><a class=\"cp-source-link cp-source-pmc\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC5549626\/\" aria-label=\"Read full text in PubMed Central\" title=\"Read full text in PubMed Central\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M8 9h12c3 0 5 2 5 5v25c0-3-2-5-5-5H8z\"\/><path d=\"M40 9H28c-2 0-3 2-3 5v25c0-3 2-5 5-5h10z\"\/><path d=\"M12 16h8m-8 6h8\"\/><\/svg><span>PMC<\/span><\/a><a class=\"cp-source-link cp-source-journal\" href=\"https:\/\/doi.org\/10.1021\/acs.jproteome.6b01026\" aria-label=\"Open the journal article\" title=\"Open the journal article\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M9 7h20l10 10v24H9z\"\/><path d=\"M29 7v10h10M15 25h18m-18 6h18\"\/><path d=\"M30 22l8-8m-6 0h6v6\"\/><\/svg><span>JOURNAL<\/span><\/a><a class=\"cp-source-link cp-source-pubmed\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28644030\/\" aria-label=\"View the PubMed abstract\" title=\"View the PubMed abstract\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><rect x=\"7\" y=\"8\" width=\"34\" height=\"32\" rx=\"3\"\/><path d=\"M13 16h22M13 23h22M13 30h14\"\/><circle cx=\"34\" cy=\"32\" r=\"4\"\/><\/svg><span>PUBMED<\/span><\/a><\/span><\/p>\n<\/li>\n<li>\n<p class=\"p1\">Y. Helou, A. Petrashen, A. Salomon. (2015). \u201cVav1 regulates T cell activation through a feedback mechanism and crosstalk between the T cell receptor and CD28.\u201d <i>J. Proteome Res.<\/i>, 14:2963\u20132975. <span class=\"cp-paper-links\" aria-label=\"Publication links\"><a class=\"cp-source-link cp-source-pmc\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4490005\/\" aria-label=\"Read full text in PubMed Central\" title=\"Read full text in PubMed Central\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M8 9h12c3 0 5 2 5 5v25c0-3-2-5-5-5H8z\"\/><path d=\"M40 9H28c-2 0-3 2-3 5v25c0-3 2-5 5-5h10z\"\/><path d=\"M12 16h8m-8 6h8\"\/><\/svg><span>PMC<\/span><\/a><a class=\"cp-source-link cp-source-journal\" href=\"https:\/\/doi.org\/10.1021\/acs.jproteome.5b00340\" aria-label=\"Open the journal article\" title=\"Open the journal article\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M9 7h20l10 10v24H9z\"\/><path d=\"M29 7v10h10M15 25h18m-18 6h18\"\/><path d=\"M30 22l8-8m-6 0h6v6\"\/><\/svg><span>JOURNAL<\/span><\/a><a class=\"cp-source-link cp-source-pubmed\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26043137\/\" aria-label=\"View the PubMed abstract\" title=\"View the PubMed abstract\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><rect x=\"7\" y=\"8\" width=\"34\" height=\"32\" rx=\"3\"\/><path d=\"M13 16h22M13 23h22M13 30h14\"\/><circle cx=\"34\" cy=\"32\" r=\"4\"\/><\/svg><span>PUBMED<\/span><\/a><\/span><\/p>\n<\/li>\n<li>\n<p class=\"p1\">H. Goodfellow, M. Frushicheva, Q. Ji, D. Cheng, A. Cantor, J. Kuriyan, A. Chakraborty*, A. Salomon*, A. Weiss*. (2015). \u201cZap70 catalytic activity regulates basal signaling and negative feedback of the proximal TCR signaling pathway.\u201d <i>Sci. Signal.<\/i>, 8(377):ra49. (*corresponding authors). <span class=\"cp-paper-links\" aria-label=\"Publication links\"><a class=\"cp-source-link cp-source-pmc\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4445242\/\" aria-label=\"Read full text in PubMed Central\" title=\"Read full text in PubMed Central\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M8 9h12c3 0 5 2 5 5v25c0-3-2-5-5-5H8z\"\/><path d=\"M40 9H28c-2 0-3 2-3 5v25c0-3 2-5 5-5h10z\"\/><path d=\"M12 16h8m-8 6h8\"\/><\/svg><span>PMC<\/span><\/a><a class=\"cp-source-link cp-source-journal\" href=\"https:\/\/doi.org\/10.1126\/scisignal.2005596\" aria-label=\"Open the journal article\" title=\"Open the journal article\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M9 7h20l10 10v24H9z\"\/><path d=\"M29 7v10h10M15 25h18m-18 6h18\"\/><path d=\"M30 22l8-8m-6 0h6v6\"\/><\/svg><span>JOURNAL<\/span><\/a><a class=\"cp-source-link cp-source-pubmed\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25990959\/\" aria-label=\"View the PubMed abstract\" title=\"View the PubMed abstract\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><rect x=\"7\" y=\"8\" width=\"34\" height=\"32\" rx=\"3\"\/><path d=\"M13 16h22M13 23h22M13 30h14\"\/><circle cx=\"34\" cy=\"32\" r=\"4\"\/><\/svg><span>PUBMED<\/span><\/a><\/span><\/p>\n<\/li>\n<li>\n<p class=\"p1\">Q. Ji, Y. Ding, A. Salomon. (2015). \u201cSRC homology 2 domain-containing leukocyte phosphoprotein of 76 kDa (SLP-76) N-terminal tyrosine residues regulate a dynamic signaling equilibrium involving feedback of proximal T-cell receptor signaling.\u201d <i>Mol. Cell. Proteomics<\/i>, 14:30\u201340. <span class=\"cp-paper-links\" aria-label=\"Publication links\"><a class=\"cp-source-link cp-source-pmc\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4288261\/\" aria-label=\"Read full text in PubMed Central\" title=\"Read full text in PubMed Central\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M8 9h12c3 0 5 2 5 5v25c0-3-2-5-5-5H8z\"\/><path d=\"M40 9H28c-2 0-3 2-3 5v25c0-3 2-5 5-5h10z\"\/><path d=\"M12 16h8m-8 6h8\"\/><\/svg><span>PMC<\/span><\/a><a class=\"cp-source-link cp-source-journal\" href=\"https:\/\/doi.org\/10.1074\/mcp.M114.037861\" aria-label=\"Open the journal article\" title=\"Open the journal article\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M9 7h20l10 10v24H9z\"\/><path d=\"M29 7v10h10M15 25h18m-18 6h18\"\/><path d=\"M30 22l8-8m-6 0h6v6\"\/><\/svg><span>JOURNAL<\/span><\/a><a class=\"cp-source-link cp-source-pubmed\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25316710\/\" aria-label=\"View the PubMed abstract\" title=\"View the PubMed abstract\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><rect x=\"7\" y=\"8\" width=\"34\" height=\"32\" rx=\"3\"\/><path d=\"M13 16h22M13 23h22M13 30h14\"\/><circle cx=\"34\" cy=\"32\" r=\"4\"\/><\/svg><span>PUBMED<\/span><\/a><\/span><\/p>\n<\/li>\n<li>\n<p class=\"p1\">Y.A. Helou, V. Nguyen, S.P. Beik, A.R. Salomon. (2013). \u201cERK positive feedback regulates a widespread network of tyrosine phosphorylation sites across canonical T cell signaling and actin cytoskeletal proteins in Jurkat T cells.\u201d <i>PLoS One<\/i>, 8(7):e69641. <span class=\"cp-paper-links\" aria-label=\"Publication links\"><a class=\"cp-source-link cp-source-pmc\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3714263\/\" aria-label=\"Read full text in PubMed Central\" title=\"Read full text in PubMed Central\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M8 9h12c3 0 5 2 5 5v25c0-3-2-5-5-5H8z\"\/><path d=\"M40 9H28c-2 0-3 2-3 5v25c0-3 2-5 5-5h10z\"\/><path d=\"M12 16h8m-8 6h8\"\/><\/svg><span>PMC<\/span><\/a><a class=\"cp-source-link cp-source-journal\" href=\"https:\/\/doi.org\/10.1371\/journal.pone.0069641\" aria-label=\"Open the journal article\" title=\"Open the journal article\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M9 7h20l10 10v24H9z\"\/><path d=\"M29 7v10h10M15 25h18m-18 6h18\"\/><path d=\"M30 22l8-8m-6 0h6v6\"\/><\/svg><span>JOURNAL<\/span><\/a><a class=\"cp-source-link cp-source-pubmed\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23874979\/\" aria-label=\"View the PubMed abstract\" title=\"View the PubMed abstract\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><rect x=\"7\" y=\"8\" width=\"34\" height=\"32\" rx=\"3\"\/><path d=\"M13 16h22M13 23h22M13 30h14\"\/><circle cx=\"34\" cy=\"32\" r=\"4\"\/><\/svg><span>PUBMED<\/span><\/a><\/span><\/p>\n<\/li>\n<li>\n<p class=\"p1\">L. Cao, Y. Ding, N. Hung, K. Yu, A. Ritz, B.J. Raphael, A.R. Salomon. (2012). \u201cQuantitative phosphoproteomics reveals SLP-76 dependent regulation of PAG and Src family kinases in T cells.\u201d <i>PLoS One<\/i>, 7(10):e46725. <span class=\"cp-paper-links\" aria-label=\"Publication links\"><a class=\"cp-source-link cp-source-pmc\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3469622\/\" aria-label=\"Read full text in PubMed Central\" title=\"Read full text in PubMed Central\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M8 9h12c3 0 5 2 5 5v25c0-3-2-5-5-5H8z\"\/><path d=\"M40 9H28c-2 0-3 2-3 5v25c0-3 2-5 5-5h10z\"\/><path d=\"M12 16h8m-8 6h8\"\/><\/svg><span>PMC<\/span><\/a><a class=\"cp-source-link cp-source-journal\" href=\"https:\/\/doi.org\/10.1371\/journal.pone.0046725\" aria-label=\"Open the journal article\" title=\"Open the journal article\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M9 7h20l10 10v24H9z\"\/><path d=\"M29 7v10h10M15 25h18m-18 6h18\"\/><path d=\"M30 22l8-8m-6 0h6v6\"\/><\/svg><span>JOURNAL<\/span><\/a><a class=\"cp-source-link cp-source-pubmed\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23071622\/\" aria-label=\"View the PubMed abstract\" title=\"View the PubMed abstract\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><rect x=\"7\" y=\"8\" width=\"34\" height=\"32\" rx=\"3\"\/><path d=\"M13 16h22M13 23h22M13 30h14\"\/><circle cx=\"34\" cy=\"32\" r=\"4\"\/><\/svg><span>PUBMED<\/span><\/a><\/span><\/p>\n<\/li>\n<li>\n<p class=\"p1\">V. Nguyen, L. Cao, J.T. Lin, N. Hung, A. Ritz, K. Yu, R. Jianu, S.P. Ulin, B.J. Raphael, D.H. Laidlaw, L. Brossay, A.R. Salomon. (2009). \u201cA new approach for quantitative phosphoproteomic dissection of signaling pathways applied to T cell receptor activation.\u201d <i>Mol. Cell. Proteomics<\/i>, 8(11):2418\u20132431. <span class=\"cp-paper-links\" aria-label=\"Publication links\"><a class=\"cp-source-link cp-source-pmc\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC2773711\/\" aria-label=\"Read full text in PubMed Central\" title=\"Read full text in PubMed Central\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M8 9h12c3 0 5 2 5 5v25c0-3-2-5-5-5H8z\"\/><path d=\"M40 9H28c-2 0-3 2-3 5v25c0-3 2-5 5-5h10z\"\/><path d=\"M12 16h8m-8 6h8\"\/><\/svg><span>PMC<\/span><\/a><a class=\"cp-source-link cp-source-journal\" href=\"https:\/\/doi.org\/10.1074\/mcp.M800307-MCP200\" aria-label=\"Open the journal article\" title=\"Open the journal article\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M9 7h20l10 10v24H9z\"\/><path d=\"M29 7v10h10M15 25h18m-18 6h18\"\/><path d=\"M30 22l8-8m-6 0h6v6\"\/><\/svg><span>JOURNAL<\/span><\/a><a class=\"cp-source-link cp-source-pubmed\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19605366\/\" aria-label=\"View the PubMed abstract\" title=\"View the PubMed abstract\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><rect x=\"7\" y=\"8\" width=\"34\" height=\"32\" rx=\"3\"\/><path d=\"M13 16h22M13 23h22M13 30h14\"\/><circle cx=\"34\" cy=\"32\" r=\"4\"\/><\/svg><span>PUBMED<\/span><\/a><\/span><\/p>\n<\/li>\n<\/ol>\n<\/li>\n<\/ol>\n<\/div>\n<h3 id=\"phosphoproteomics\" class=\"p1\"><b>Advancing Quantitative Phosphoproteomics for Immune Signaling<\/b><\/h3>\n<figure class=\"cp-section-figure\"><a class=\"cp-section-figure-link\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12157578\/\" target=\"_blank\" rel=\"noopener noreferrer\"><img width=\"1225\" height=\"1189\" src=\"https:\/\/cellpathway.com\/wp-content\/uploads\/2026\/07\/cellpathway-phosphoproteomics-hires.png\" class=\"cp-section-figure-image\" alt=\"High-resolution phosphoproteomics workflow from T cell stimulation through LC-MS\/MS analysis\" loading=\"lazy\" decoding=\"async\" srcset=\"https:\/\/cellpathway.com\/wp-content\/uploads\/2026\/07\/cellpathway-phosphoproteomics-hires.png 1225w, https:\/\/cellpathway.com\/wp-content\/uploads\/2026\/07\/cellpathway-phosphoproteomics-hires-300x291.png 300w, https:\/\/cellpathway.com\/wp-content\/uploads\/2026\/07\/cellpathway-phosphoproteomics-hires-1024x994.png 1024w, https:\/\/cellpathway.com\/wp-content\/uploads\/2026\/07\/cellpathway-phosphoproteomics-hires-768x745.png 768w\" sizes=\"auto, (max-width: 1225px) 100vw, 1225px\" \/><\/a><figcaption><strong>Experimental workflow linking T-cell stimulation, sample preparation, phosphotyrosine enrichment, LC-MS\/MS, and data analysis.<\/strong> <span>Source: <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12157578\/\" target=\"_blank\" rel=\"noopener noreferrer\">Callahan et al., bioRxiv (2025), Figure 1<\/a> \u00b7 <a href=\"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\" target=\"_blank\" rel=\"license noopener noreferrer\">CC BY-NC 4.0<\/a>.<\/span><\/figcaption><\/figure>\n<p class=\"p1\">Our laboratory has helped advance quantitative phosphoproteomics into a powerful framework for systems-level analysis of immune signaling. Early work from our group was among the first to demonstrate that mass spectrometry could be used to map tyrosine phosphorylation pathways on a broad scale in human cells, moving the field beyond one-protein-at-a-time studies toward global, quantitative analysis of signaling networks. We have since continued to expand the depth, reproducibility, and interpretability of these methods through improved phosphopeptide enrichment, optimized LC-MS workflows, BOOST-based strategies for deeper phosphotyrosine characterization, quantitative interactomics in living T cells, and recent evaluation of high-capacity first-pass desalting approaches that improve sample handling and support robust phosphoproteomics workflows. Together, these advances have strengthened the technical foundation for discovering signaling mechanisms in T cells and other immune systems and have provided broadly useful tools for studying cancer, infection, and immune-mediated disease.<\/p>\n<div style=\"width: 100%; background: #eeeeee; padding: 5px 0 5px 5px;\">\n<h4>Our publications in this Area<\/h4>\n<ol start=\"1\">\n<li>\n<p class=\"p1\">A. Callahan, A. Mojumdar, A.R. Salomon, N.A. DaSilva*. (2025). \u201cEvaluating first-pass, high protein capacity desalting techniques for phosphoproteomics applications.\u201d <i>bioRxiv<\/i>, 2025.06.03.657744. doi:10.1101\/2025.06.03.657744. (*corresponding author) . <span class=\"cp-paper-links\" aria-label=\"Publication links\"><a class=\"cp-source-link cp-source-pmc\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12157578\/\" aria-label=\"Read full text in PubMed Central\" title=\"Read full text in PubMed Central\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M8 9h12c3 0 5 2 5 5v25c0-3-2-5-5-5H8z\"\/><path d=\"M40 9H28c-2 0-3 2-3 5v25c0-3 2-5 5-5h10z\"\/><path d=\"M12 16h8m-8 6h8\"\/><\/svg><span>PMC<\/span><\/a><a class=\"cp-source-link cp-source-journal\" href=\"https:\/\/doi.org\/10.1101\/2025.06.03.657744\" aria-label=\"Open the journal article\" title=\"Open the journal article\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M9 7h20l10 10v24H9z\"\/><path d=\"M29 7v10h10M15 25h18m-18 6h18\"\/><path d=\"M30 22l8-8m-6 0h6v6\"\/><\/svg><span>JOURNAL<\/span><\/a><a class=\"cp-source-link cp-source-pubmed\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40501759\/\" aria-label=\"View the PubMed abstract\" title=\"View the PubMed abstract\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><rect x=\"7\" y=\"8\" width=\"34\" height=\"32\" rx=\"3\"\/><path d=\"M13 16h22M13 23h22M13 30h14\"\/><circle cx=\"34\" cy=\"32\" r=\"4\"\/><\/svg><span>PUBMED<\/span><\/a><\/span><\/p>\n<\/li>\n<li>\n<p class=\"p1\">A. Callahan, X. Chua, A. Griffith, T. Hildebrandt, G. Fu, M. Hu, R. Wen, A. Salomon. (2024). \u201cDeep phosphotyrosine characterization of primary murine T cells using broad spectrum optimization of selective triggering.\u201d <i>Proteomics<\/i>, 24:e2400106. <span class=\"cp-paper-links\" aria-label=\"Publication links\"><a class=\"cp-source-link cp-source-pmc\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11684461\/\" aria-label=\"Read full text in PubMed Central\" title=\"Read full text in PubMed Central\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M8 9h12c3 0 5 2 5 5v25c0-3-2-5-5-5H8z\"\/><path d=\"M40 9H28c-2 0-3 2-3 5v25c0-3 2-5 5-5h10z\"\/><path d=\"M12 16h8m-8 6h8\"\/><\/svg><span>PMC<\/span><\/a><a class=\"cp-source-link cp-source-journal\" href=\"https:\/\/doi.org\/10.1002\/pmic.202400106\" aria-label=\"Open the journal article\" title=\"Open the journal article\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M9 7h20l10 10v24H9z\"\/><path d=\"M29 7v10h10M15 25h18m-18 6h18\"\/><path d=\"M30 22l8-8m-6 0h6v6\"\/><\/svg><span>JOURNAL<\/span><\/a><a class=\"cp-source-link cp-source-pubmed\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39091061\/\" aria-label=\"View the PubMed abstract\" title=\"View the PubMed abstract\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><rect x=\"7\" y=\"8\" width=\"34\" height=\"32\" rx=\"3\"\/><path d=\"M13 16h22M13 23h22M13 30h14\"\/><circle cx=\"34\" cy=\"32\" r=\"4\"\/><\/svg><span>PUBMED<\/span><\/a><\/span><\/p>\n<\/li>\n<li>\n<p class=\"p1\">X. Chua, A. Salomon. (2021). \u201cQuantitative interactomics of Lck-TurboID in living human T cells unveils T cell receptor stimulation-induced proximal Lck interactors.\u201d <i>J. Proteome Res.<\/i>, 20(1):715\u2013726. <span class=\"cp-paper-links\" aria-label=\"Publication links\"><a class=\"cp-source-link cp-source-pmc\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7962135\/\" aria-label=\"Read full text in PubMed Central\" title=\"Read full text in PubMed Central\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M8 9h12c3 0 5 2 5 5v25c0-3-2-5-5-5H8z\"\/><path d=\"M40 9H28c-2 0-3 2-3 5v25c0-3 2-5 5-5h10z\"\/><path d=\"M12 16h8m-8 6h8\"\/><\/svg><span>PMC<\/span><\/a><a class=\"cp-source-link cp-source-journal\" href=\"https:\/\/doi.org\/10.1021\/acs.jproteome.0c00616\" aria-label=\"Open the journal article\" title=\"Open the journal article\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M9 7h20l10 10v24H9z\"\/><path d=\"M29 7v10h10M15 25h18m-18 6h18\"\/><path d=\"M30 22l8-8m-6 0h6v6\"\/><\/svg><span>JOURNAL<\/span><\/a><a class=\"cp-source-link cp-source-pubmed\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33185455\/\" aria-label=\"View the PubMed abstract\" title=\"View the PubMed abstract\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><rect x=\"7\" y=\"8\" width=\"34\" height=\"32\" rx=\"3\"\/><path d=\"M13 16h22M13 23h22M13 30h14\"\/><circle cx=\"34\" cy=\"32\" r=\"4\"\/><\/svg><span>PUBMED<\/span><\/a><\/span><\/p>\n<\/li>\n<li>\n<p class=\"p1\">X. Chua, T. Mensah, T. Aballo, S. Mackintosh, R. Edmondson, A. Salomon. (2020). \u201cTandem mass tag approach utilizing pervanadate BOOST channels delivers deeper quantitative characterization of the tyrosine phosphoproteome.\u201d <i>Mol. Cell. Proteomics<\/i>, 19:730\u2013743. <span class=\"cp-paper-links\" aria-label=\"Publication links\"><a class=\"cp-source-link cp-source-pmc\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7124467\/\" aria-label=\"Read full text in PubMed Central\" title=\"Read full text in PubMed Central\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M8 9h12c3 0 5 2 5 5v25c0-3-2-5-5-5H8z\"\/><path d=\"M40 9H28c-2 0-3 2-3 5v25c0-3 2-5 5-5h10z\"\/><path d=\"M12 16h8m-8 6h8\"\/><\/svg><span>PMC<\/span><\/a><a class=\"cp-source-link cp-source-journal\" href=\"https:\/\/doi.org\/10.1074\/mcp.TIR119.001865\" aria-label=\"Open the journal article\" title=\"Open the journal article\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M9 7h20l10 10v24H9z\"\/><path d=\"M29 7v10h10M15 25h18m-18 6h18\"\/><path d=\"M30 22l8-8m-6 0h6v6\"\/><\/svg><span>JOURNAL<\/span><\/a><a class=\"cp-source-link cp-source-pubmed\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32071147\/\" aria-label=\"View the PubMed abstract\" title=\"View the PubMed abstract\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><rect x=\"7\" y=\"8\" width=\"34\" height=\"32\" rx=\"3\"\/><path d=\"M13 16h22M13 23h22M13 30h14\"\/><circle cx=\"34\" cy=\"32\" r=\"4\"\/><\/svg><span>PUBMED<\/span><\/a><\/span><\/p>\n<\/li>\n<li>\n<p class=\"p1\">N. Ahsan, A. Salomon. (2017). \u201cQuantitative phosphoproteomic analysis of T-cell receptor signaling.\u201d <i>Methods Mol. Biol.<\/i>, 1584:369\u2013382. <span class=\"cp-paper-links\" aria-label=\"Publication links\"><a class=\"cp-source-link cp-source-pmc\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC5573147\/\" aria-label=\"Read full text in PubMed Central\" title=\"Read full text in PubMed Central\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M8 9h12c3 0 5 2 5 5v25c0-3-2-5-5-5H8z\"\/><path d=\"M40 9H28c-2 0-3 2-3 5v25c0-3 2-5 5-5h10z\"\/><path d=\"M12 16h8m-8 6h8\"\/><\/svg><span>PMC<\/span><\/a><a class=\"cp-source-link cp-source-journal\" href=\"https:\/\/doi.org\/10.1007\/978-1-4939-6881-7_22\" aria-label=\"Open the journal article\" title=\"Open the journal article\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M9 7h20l10 10v24H9z\"\/><path d=\"M29 7v10h10M15 25h18m-18 6h18\"\/><path d=\"M30 22l8-8m-6 0h6v6\"\/><\/svg><span>JOURNAL<\/span><\/a><a class=\"cp-source-link cp-source-pubmed\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28255713\/\" aria-label=\"View the PubMed abstract\" title=\"View the PubMed abstract\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><rect x=\"7\" y=\"8\" width=\"34\" height=\"32\" rx=\"3\"\/><path d=\"M13 16h22M13 23h22M13 30h14\"\/><circle cx=\"34\" cy=\"32\" r=\"4\"\/><\/svg><span>PUBMED<\/span><\/a><\/span><\/p>\n<\/li>\n<li>\n<p class=\"p1\">N. Ahsan, J. Belmont, Z. Chen, J. Clifton, A. Salomon. (2017). \u201cHighly reproducible improved label-free quantitative analysis of cellular phosphoproteome by optimization of LC-MS\/MS gradient and analytical column construction.\u201d <i>J. Proteomics<\/i>, 165:69\u201374. <span class=\"cp-paper-links\" aria-label=\"Publication links\"><a class=\"cp-source-link cp-source-pmc\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC5542054\/\" aria-label=\"Read full text in PubMed Central\" title=\"Read full text in PubMed Central\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M8 9h12c3 0 5 2 5 5v25c0-3-2-5-5-5H8z\"\/><path d=\"M40 9H28c-2 0-3 2-3 5v25c0-3 2-5 5-5h10z\"\/><path d=\"M12 16h8m-8 6h8\"\/><\/svg><span>PMC<\/span><\/a><a class=\"cp-source-link cp-source-journal\" href=\"https:\/\/doi.org\/10.1016\/j.jprot.2017.06.013\" aria-label=\"Open the journal article\" title=\"Open the journal article\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M9 7h20l10 10v24H9z\"\/><path d=\"M29 7v10h10M15 25h18m-18 6h18\"\/><path d=\"M30 22l8-8m-6 0h6v6\"\/><\/svg><span>JOURNAL<\/span><\/a><a class=\"cp-source-link cp-source-pubmed\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28634120\/\" aria-label=\"View the PubMed abstract\" title=\"View the PubMed abstract\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><rect x=\"7\" y=\"8\" width=\"34\" height=\"32\" rx=\"3\"\/><path d=\"M13 16h22M13 23h22M13 30h14\"\/><circle cx=\"34\" cy=\"32\" r=\"4\"\/><\/svg><span>PUBMED<\/span><\/a><\/span><\/p>\n<\/li>\n<li>\n<p class=\"p1\">N\u00fchse, T., K. Yu, A. Salomon. (2007). \u201cIsolation of phosphopeptides by immobilized metal ion affinity chromatography.\u201d <i>Curr. Protoc. Mol. Biol.<\/i>, Chapter 18:Unit 18.13.. <span class=\"cp-paper-links\" aria-label=\"Publication links\"><a class=\"cp-source-link cp-source-journal\" href=\"https:\/\/doi.org\/10.1002\/0471142727.mb1813s77\" aria-label=\"Open the journal article\" title=\"Open the journal article\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M9 7h20l10 10v24H9z\"\/><path d=\"M29 7v10h10M15 25h18m-18 6h18\"\/><path d=\"M30 22l8-8m-6 0h6v6\"\/><\/svg><span>JOURNAL<\/span><\/a><a class=\"cp-source-link cp-source-pubmed\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18265394\/\" aria-label=\"View the PubMed abstract\" title=\"View the PubMed abstract\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><rect x=\"7\" y=\"8\" width=\"34\" height=\"32\" rx=\"3\"\/><path d=\"M13 16h22M13 23h22M13 30h14\"\/><circle cx=\"34\" cy=\"32\" r=\"4\"\/><\/svg><span>PUBMED<\/span><\/a><\/span><\/p>\n<\/li>\n<li>\n<p class=\"p1\">S.B. Ficarro, A.R. Salomon, L.M. Brill, D.E. Mason, M. Stettler-Gill, A. Brock, E.C. Peters. (2005). \u201cAutomated immobilized metal affinity chromatography\/nano-liquid chromatography\/electrospray ionization mass spectrometry platform for profiling protein phosphorylation sites.\u201d <i>Rapid Commun. Mass Spectrom.<\/i>, 19(1):57\u201371.. <span class=\"cp-paper-links\" aria-label=\"Publication links\"><a class=\"cp-source-link cp-source-journal\" href=\"https:\/\/doi.org\/10.1002\/rcm.1746\" aria-label=\"Open the journal article\" title=\"Open the journal article\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M9 7h20l10 10v24H9z\"\/><path d=\"M29 7v10h10M15 25h18m-18 6h18\"\/><path d=\"M30 22l8-8m-6 0h6v6\"\/><\/svg><span>JOURNAL<\/span><\/a><a class=\"cp-source-link cp-source-pubmed\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15570572\/\" aria-label=\"View the PubMed abstract\" title=\"View the PubMed abstract\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><rect x=\"7\" y=\"8\" width=\"34\" height=\"32\" rx=\"3\"\/><path d=\"M13 16h22M13 23h22M13 30h14\"\/><circle cx=\"34\" cy=\"32\" r=\"4\"\/><\/svg><span>PUBMED<\/span><\/a><\/span><\/p>\n<\/li>\n<li>\n<p class=\"p1\">L.M. Brill, A.R. Salomon, S.B. Ficarro, M. Mukherji, M. Stettler-Gill, E.C. Peters. (2004). \u201cRobust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.\u201d <i>Anal. Chem.<\/i>, 76(10):2763\u20132772.. <span class=\"cp-paper-links\" aria-label=\"Publication links\"><a class=\"cp-source-link cp-source-journal\" href=\"https:\/\/doi.org\/10.1021\/ac035352d\" aria-label=\"Open the journal article\" title=\"Open the journal article\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M9 7h20l10 10v24H9z\"\/><path d=\"M29 7v10h10M15 25h18m-18 6h18\"\/><path d=\"M30 22l8-8m-6 0h6v6\"\/><\/svg><span>JOURNAL<\/span><\/a><a class=\"cp-source-link cp-source-pubmed\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15144186\/\" aria-label=\"View the PubMed abstract\" title=\"View the PubMed abstract\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><rect x=\"7\" y=\"8\" width=\"34\" height=\"32\" rx=\"3\"\/><path d=\"M13 16h22M13 23h22M13 30h14\"\/><circle cx=\"34\" cy=\"32\" r=\"4\"\/><\/svg><span>PUBMED<\/span><\/a><\/span><\/p>\n<\/li>\n<li>\n<p class=\"p1\">A. Salomon, S. Ficarro, L. Brill, A. Brinker, Q. Phung, C. Ericson, K. Sauer, A. Brock, D. Horn, P. Schultz, E. Peters. (2003). \u201cProfiling of tyrosine phosphorylation pathways in human cells using mass spectrometry.\u201d <i>Proc. Natl. Acad. Sci. U.S.A.<\/i>, 100(2):443\u2013448. <span class=\"cp-paper-links\" aria-label=\"Publication links\"><a class=\"cp-source-link cp-source-pmc\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC141014\/\" aria-label=\"Read full text in PubMed Central\" title=\"Read full text in PubMed Central\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M8 9h12c3 0 5 2 5 5v25c0-3-2-5-5-5H8z\"\/><path d=\"M40 9H28c-2 0-3 2-3 5v25c0-3 2-5 5-5h10z\"\/><path d=\"M12 16h8m-8 6h8\"\/><\/svg><span>PMC<\/span><\/a><a class=\"cp-source-link cp-source-journal\" href=\"https:\/\/doi.org\/10.1073\/pnas.2436191100\" aria-label=\"Open the journal article\" title=\"Open the journal article\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M9 7h20l10 10v24H9z\"\/><path d=\"M29 7v10h10M15 25h18m-18 6h18\"\/><path d=\"M30 22l8-8m-6 0h6v6\"\/><\/svg><span>JOURNAL<\/span><\/a><a class=\"cp-source-link cp-source-pubmed\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/12522270\/\" aria-label=\"View the PubMed abstract\" title=\"View the PubMed abstract\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><rect x=\"7\" y=\"8\" width=\"34\" height=\"32\" rx=\"3\"\/><path d=\"M13 16h22M13 23h22M13 30h14\"\/><circle cx=\"34\" cy=\"32\" r=\"4\"\/><\/svg><span>PUBMED<\/span><\/a><\/span><\/p>\n<\/li>\n<\/ol>\n<\/div>\n<h3 id=\"computational-platforms\" class=\"p1\"><strong>Computational Platforms Enabling Quantitative Proteomics and Network Analysis<\/strong><\/h3>\n<figure class=\"cp-section-figure\"><a class=\"cp-section-figure-link\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC2872116\/\" target=\"_blank\" rel=\"noopener noreferrer\"><img width=\"1900\" height=\"1134\" src=\"https:\/\/cellpathway.com\/wp-content\/uploads\/2026\/07\/cellpathway-computational-hires.jpg\" class=\"cp-section-figure-image\" alt=\"High-resolution software interface integrating quantitative proteomics with a T cell signaling network\" loading=\"lazy\" decoding=\"async\" srcset=\"https:\/\/cellpathway.com\/wp-content\/uploads\/2026\/07\/cellpathway-computational-hires.jpg 1900w, https:\/\/cellpathway.com\/wp-content\/uploads\/2026\/07\/cellpathway-computational-hires-300x179.jpg 300w, https:\/\/cellpathway.com\/wp-content\/uploads\/2026\/07\/cellpathway-computational-hires-1024x611.jpg 1024w, https:\/\/cellpathway.com\/wp-content\/uploads\/2026\/07\/cellpathway-computational-hires-768x458.jpg 768w, https:\/\/cellpathway.com\/wp-content\/uploads\/2026\/07\/cellpathway-computational-hires-1536x917.jpg 1536w\" sizes=\"auto, (max-width: 1900px) 100vw, 1900px\" \/><\/a><figcaption><strong>Interactive integration of quantitative proteomic measurements with pathway and protein-interaction networks.<\/strong> <span>Source: <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC2872116\/\" target=\"_blank\" rel=\"noopener noreferrer\">Jianu et al., IEEE Transactions on Visualization and Computer Graphics (2010), Figure 1<\/a>.<\/span><\/figcaption><\/figure>\n<p class=\"p1\">Our laboratory has helped develop computational tools that make large-scale proteomics more rigorous, interpretable, and biologically informative. This work includes platforms for automated proteomic data processing, statistical validation of tandem mass spectra, relational database organization of quantitative datasets, discovery of phosphorylation motifs, and visualization of phosphoproteomic data in the context of signaling pathways and protein interaction networks. Together, these efforts have expanded the analytical infrastructure needed to move from raw mass spectrometry data to biological insight. More recent studies have integrated these computational advances with quantitative phosphoproteomic workflows to interpret complex T cell signaling responses at the systems level. These tools have helped advance the field by enabling deeper, more reproducible, and more mechanistic analysis of signaling networks relevant to immunology, cancer, and human disease.<\/p>\n<div style=\"width: 100%; background: #eeeeee; padding: 5px 0 5px 5px;\">\n<h4>Our publications in this Area<\/h4>\n<ol start=\"1\">\n<li>\n<p class=\"p1\">X. Chua, A. Salomon. (2021). \u201cOvalbumin antigen-specific activation of human T cell receptor closely resembles soluble antibody stimulation as revealed by BOOST phosphotyrosine proteomics.\u201d <i>J. Proteome Res.<\/i>, 20(6):3330\u20133344. <span class=\"cp-paper-links\" aria-label=\"Publication links\"><a class=\"cp-source-link cp-source-pmc\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8626127\/\" aria-label=\"Read full text in PubMed Central\" title=\"Read full text in PubMed Central\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M8 9h12c3 0 5 2 5 5v25c0-3-2-5-5-5H8z\"\/><path d=\"M40 9H28c-2 0-3 2-3 5v25c0-3 2-5 5-5h10z\"\/><path d=\"M12 16h8m-8 6h8\"\/><\/svg><span>PMC<\/span><\/a><a class=\"cp-source-link cp-source-journal\" href=\"https:\/\/doi.org\/10.1021\/acs.jproteome.1c00239\" aria-label=\"Open the journal article\" title=\"Open the journal article\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M9 7h20l10 10v24H9z\"\/><path d=\"M29 7v10h10M15 25h18m-18 6h18\"\/><path d=\"M30 22l8-8m-6 0h6v6\"\/><\/svg><span>JOURNAL<\/span><\/a><a class=\"cp-source-link cp-source-pubmed\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34018748\/\" aria-label=\"View the PubMed abstract\" title=\"View the PubMed abstract\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><rect x=\"7\" y=\"8\" width=\"34\" height=\"32\" rx=\"3\"\/><path d=\"M13 16h22M13 23h22M13 30h14\"\/><circle cx=\"34\" cy=\"32\" r=\"4\"\/><\/svg><span>PUBMED<\/span><\/a><\/span><\/p>\n<\/li>\n<li>\n<p class=\"p1\">K. Yu, A. Salomon. (2010). \u201cHTAPP: High-throughput autonomous proteomic pipeline.\u201d <i>Proteomics<\/i>, 10:2113\u20132122.. <span class=\"cp-paper-links\" aria-label=\"Publication links\"><a class=\"cp-source-link cp-source-pmc\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3214964\/\" aria-label=\"Read full text in PubMed Central\" title=\"Read full text in PubMed Central\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M8 9h12c3 0 5 2 5 5v25c0-3-2-5-5-5H8z\"\/><path d=\"M40 9H28c-2 0-3 2-3 5v25c0-3 2-5 5-5h10z\"\/><path d=\"M12 16h8m-8 6h8\"\/><\/svg><span>PMC<\/span><\/a><a class=\"cp-source-link cp-source-journal\" href=\"https:\/\/doi.org\/10.1002\/pmic.200900159\" aria-label=\"Open the journal article\" title=\"Open the journal article\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M9 7h20l10 10v24H9z\"\/><path d=\"M29 7v10h10M15 25h18m-18 6h18\"\/><path d=\"M30 22l8-8m-6 0h6v6\"\/><\/svg><span>JOURNAL<\/span><\/a><a class=\"cp-source-link cp-source-pubmed\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20336676\/\" aria-label=\"View the PubMed abstract\" title=\"View the PubMed abstract\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><rect x=\"7\" y=\"8\" width=\"34\" height=\"32\" rx=\"3\"\/><path d=\"M13 16h22M13 23h22M13 30h14\"\/><circle cx=\"34\" cy=\"32\" r=\"4\"\/><\/svg><span>PUBMED<\/span><\/a><\/span><\/p>\n<\/li>\n<li>\n<p class=\"p1\">R. Jianu, K. Yu, L. Cao, V. Nguyen, A. Salomon, D. Laidlaw. (2010). \u201cVisual integration of quantitative proteomic data, pathways and protein interactions.\u201d <i>IEEE Trans. Vis. Comput. Graph.<\/i>, 16(4):609\u2013620. <span class=\"cp-paper-links\" aria-label=\"Publication links\"><a class=\"cp-source-link cp-source-pmc\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC2872116\/\" aria-label=\"Read full text in PubMed Central\" title=\"Read full text in PubMed Central\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M8 9h12c3 0 5 2 5 5v25c0-3-2-5-5-5H8z\"\/><path d=\"M40 9H28c-2 0-3 2-3 5v25c0-3 2-5 5-5h10z\"\/><path d=\"M12 16h8m-8 6h8\"\/><\/svg><span>PMC<\/span><\/a><a class=\"cp-source-link cp-source-journal\" href=\"https:\/\/doi.org\/10.1109\/TVCG.2009.106\" aria-label=\"Open the journal article\" title=\"Open the journal article\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M9 7h20l10 10v24H9z\"\/><path d=\"M29 7v10h10M15 25h18m-18 6h18\"\/><path d=\"M30 22l8-8m-6 0h6v6\"\/><\/svg><span>JOURNAL<\/span><\/a><a class=\"cp-source-link cp-source-pubmed\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20467059\/\" aria-label=\"View the PubMed abstract\" title=\"View the PubMed abstract\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><rect x=\"7\" y=\"8\" width=\"34\" height=\"32\" rx=\"3\"\/><path d=\"M13 16h22M13 23h22M13 30h14\"\/><circle cx=\"34\" cy=\"32\" r=\"4\"\/><\/svg><span>PUBMED<\/span><\/a><\/span><\/p>\n<\/li>\n<li>\n<p class=\"p1\">A. Ritz, G. Shakhnarovich, A. Salomon, B. Raphael. (2009). \u201cDiscovery of phosphorylation motif mixtures in phosphoproteomics data.\u201d <i>Bioinformatics<\/i>, 25(1):14\u201321.. <span class=\"cp-paper-links\" aria-label=\"Publication links\"><a class=\"cp-source-link cp-source-pmc\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC2638929\/\" aria-label=\"Read full text in PubMed Central\" title=\"Read full text in PubMed Central\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M8 9h12c3 0 5 2 5 5v25c0-3-2-5-5-5H8z\"\/><path d=\"M40 9H28c-2 0-3 2-3 5v25c0-3 2-5 5-5h10z\"\/><path d=\"M12 16h8m-8 6h8\"\/><\/svg><span>PMC<\/span><\/a><a class=\"cp-source-link cp-source-journal\" href=\"https:\/\/doi.org\/10.1093\/bioinformatics\/btn569\" aria-label=\"Open the journal article\" title=\"Open the journal article\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M9 7h20l10 10v24H9z\"\/><path d=\"M29 7v10h10M15 25h18m-18 6h18\"\/><path d=\"M30 22l8-8m-6 0h6v6\"\/><\/svg><span>JOURNAL<\/span><\/a><a class=\"cp-source-link cp-source-pubmed\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18996944\/\" aria-label=\"View the PubMed abstract\" title=\"View the PubMed abstract\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><rect x=\"7\" y=\"8\" width=\"34\" height=\"32\" rx=\"3\"\/><path d=\"M13 16h22M13 23h22M13 30h14\"\/><circle cx=\"34\" cy=\"32\" r=\"4\"\/><\/svg><span>PUBMED<\/span><\/a><\/span><\/p>\n<\/li>\n<li>\n<p class=\"p1\">K. Yu, A. Sabelli, L. DeKeukelaere, R. Park, S. Sindi, C.A. Gatsonis, A. Salomon. (2009). \u201cIntegrated platform for manual and high-throughput statistical validation of tandem mass spectra.\u201d <i>Proteomics<\/i>, 9(11):3115\u20133125.. <span class=\"cp-paper-links\" aria-label=\"Publication links\"><a class=\"cp-source-link cp-source-pmc\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3122135\/\" aria-label=\"Read full text in PubMed Central\" title=\"Read full text in PubMed Central\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M8 9h12c3 0 5 2 5 5v25c0-3-2-5-5-5H8z\"\/><path d=\"M40 9H28c-2 0-3 2-3 5v25c0-3 2-5 5-5h10z\"\/><path d=\"M12 16h8m-8 6h8\"\/><\/svg><span>PMC<\/span><\/a><a class=\"cp-source-link cp-source-journal\" href=\"https:\/\/doi.org\/10.1002\/pmic.200800899\" aria-label=\"Open the journal article\" title=\"Open the journal article\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M9 7h20l10 10v24H9z\"\/><path d=\"M29 7v10h10M15 25h18m-18 6h18\"\/><path d=\"M30 22l8-8m-6 0h6v6\"\/><\/svg><span>JOURNAL<\/span><\/a><a class=\"cp-source-link cp-source-pubmed\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19526561\/\" aria-label=\"View the PubMed abstract\" title=\"View the PubMed abstract\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><rect x=\"7\" y=\"8\" width=\"34\" height=\"32\" rx=\"3\"\/><path d=\"M13 16h22M13 23h22M13 30h14\"\/><circle cx=\"34\" cy=\"32\" r=\"4\"\/><\/svg><span>PUBMED<\/span><\/a><\/span><\/p>\n<\/li>\n<li>\n<p class=\"p1\">K. Yu, A. Salomon. (2009). \u201cPeptideDepot: Flexible relational database for visual analysis of quantitative proteomic data and integration of existing protein information.\u201d <i>Proteomics<\/i>, 9(23):5350\u20135358.. <span class=\"cp-paper-links\" aria-label=\"Publication links\"><a class=\"cp-source-link cp-source-pmc\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC2831646\/\" aria-label=\"Read full text in PubMed Central\" title=\"Read full text in PubMed Central\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M8 9h12c3 0 5 2 5 5v25c0-3-2-5-5-5H8z\"\/><path d=\"M40 9H28c-2 0-3 2-3 5v25c0-3 2-5 5-5h10z\"\/><path d=\"M12 16h8m-8 6h8\"\/><\/svg><span>PMC<\/span><\/a><a class=\"cp-source-link cp-source-journal\" href=\"https:\/\/doi.org\/10.1002\/pmic.200900119\" aria-label=\"Open the journal article\" title=\"Open the journal article\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M9 7h20l10 10v24H9z\"\/><path d=\"M29 7v10h10M15 25h18m-18 6h18\"\/><path d=\"M30 22l8-8m-6 0h6v6\"\/><\/svg><span>JOURNAL<\/span><\/a><a class=\"cp-source-link cp-source-pubmed\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19834895\/\" aria-label=\"View the PubMed abstract\" title=\"View the PubMed abstract\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><rect x=\"7\" y=\"8\" width=\"34\" height=\"32\" rx=\"3\"\/><path d=\"M13 16h22M13 23h22M13 30h14\"\/><circle cx=\"34\" cy=\"32\" r=\"4\"\/><\/svg><span>PUBMED<\/span><\/a><\/span><\/p>\n<\/li>\n<\/ol>\n<\/div>\n<h3 id=\"human-disease\" class=\"p1\"><b>Collaborative Applications of Quantitative Proteomics in Human Disease<\/b><\/h3>\n<figure class=\"cp-section-figure\"><a class=\"cp-section-figure-link\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6326875\/\" target=\"_blank\" rel=\"noopener noreferrer\"><img width=\"996\" height=\"996\" src=\"https:\/\/cellpathway.com\/wp-content\/uploads\/2026\/07\/cellpathway-curtis-graphical-abstract.jpg\" class=\"cp-section-figure-image\" alt=\"Graphical abstract showing cancer-associated fibroblast signaling, glycogen mobilization, and ovarian cancer metastasis\" loading=\"lazy\" decoding=\"async\" srcset=\"https:\/\/cellpathway.com\/wp-content\/uploads\/2026\/07\/cellpathway-curtis-graphical-abstract.jpg 996w, https:\/\/cellpathway.com\/wp-content\/uploads\/2026\/07\/cellpathway-curtis-graphical-abstract-300x300.jpg 300w, https:\/\/cellpathway.com\/wp-content\/uploads\/2026\/07\/cellpathway-curtis-graphical-abstract-150x150.jpg 150w, https:\/\/cellpathway.com\/wp-content\/uploads\/2026\/07\/cellpathway-curtis-graphical-abstract-768x768.jpg 768w\" sizes=\"auto, (max-width: 996px) 100vw, 996px\" \/><\/a><figcaption><strong>Cancer-associated fibroblasts drive glycogen mobilization, glycolysis, proliferation, invasion, and metastasis in ovarian cancer cells.<\/strong> <span>Source: <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6326875\/\" target=\"_blank\" rel=\"noopener noreferrer\">Curtis et al., Cell Metabolism (2019), Graphical Abstract<\/a>.<\/span><\/figcaption><\/figure>\n<p class=\"p1\">Our laboratory has a strong track record of collaborative research that applies quantitative proteomics, phosphoproteomics, and signaling-network analysis to important problems across biomedicine. Working with investigators in cancer biology, immunology, metabolism, liver biology, and mitochondrial research, we have helped define signaling mechanisms that regulate tumor growth and metastasis, cancer stemness, adipose inflammation, hepatic signaling, and mitochondrial respiration and apoptosis. These studies illustrate the broad utility of proteomic approaches for uncovering mechanisms of human disease and reflect our lab\u2019s role as a collaborative partner in translating complex signaling data into biological and biomedical insight.<\/p>\n<div style=\"width: 100%; background: #eeeeee; padding: 5px 0 5px 5px;\">\n<h4>Our publications in this Area<\/h4>\n<ol start=\"1\">\n<li>\n<p class=\"p1\">M. Curtis, H. Kenny, B. Ashcroft, A. Mukherjee, A. Johnson, Y. Zhang, Y. Helou, R. Batlle, X. Liu, N. Gutierrez, X. Gao, S. Yamada, R. Lastra, A. Montag, N. Ahsan, J. Locasale, A. Salomon, A. Nebreda, E. Lengyel. (2019). \u201cFibroblasts mobilize tumor cell glycogen to promote proliferation and metastasis.\u201d <i>Cell Metab.<\/i>, 29:141\u2013155. <span class=\"cp-paper-links\" aria-label=\"Publication links\"><a class=\"cp-source-link cp-source-pmc\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6326875\/\" aria-label=\"Read full text in PubMed Central\" title=\"Read full text in PubMed Central\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M8 9h12c3 0 5 2 5 5v25c0-3-2-5-5-5H8z\"\/><path d=\"M40 9H28c-2 0-3 2-3 5v25c0-3 2-5 5-5h10z\"\/><path d=\"M12 16h8m-8 6h8\"\/><\/svg><span>PMC<\/span><\/a><a class=\"cp-source-link cp-source-journal\" href=\"https:\/\/doi.org\/10.1016\/j.cmet.2018.08.007\" aria-label=\"Open the journal article\" title=\"Open the journal article\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M9 7h20l10 10v24H9z\"\/><path d=\"M29 7v10h10M15 25h18m-18 6h18\"\/><path d=\"M30 22l8-8m-6 0h6v6\"\/><\/svg><span>JOURNAL<\/span><\/a><a class=\"cp-source-link cp-source-pubmed\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30174305\/\" aria-label=\"View the PubMed abstract\" title=\"View the PubMed abstract\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><rect x=\"7\" y=\"8\" width=\"34\" height=\"32\" rx=\"3\"\/><path d=\"M13 16h22M13 23h22M13 30h14\"\/><circle cx=\"34\" cy=\"32\" r=\"4\"\/><\/svg><span>PUBMED<\/span><\/a><\/span><\/p>\n<\/li>\n<li>\n<p class=\"p1\">J. Wan, H. Kalpage, A. Vaishnav, J. Liu, I. Lee, G. Mahapatra, A. Turner, M. Zurek, Q. Ji, C. Moraes, M. Recanati, L. Grossman, A. Salomon, B. Edwards, M. H\u00fcttemann. (2019). \u201cRegulation of respiration and apoptosis by cytochrome c threonine 58 phosphorylation.\u201d <i>Sci. Rep.<\/i>, 9(1):15815. <span class=\"cp-paper-links\" aria-label=\"Publication links\"><a class=\"cp-source-link cp-source-pmc\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6825195\/\" aria-label=\"Read full text in PubMed Central\" title=\"Read full text in PubMed Central\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M8 9h12c3 0 5 2 5 5v25c0-3-2-5-5-5H8z\"\/><path d=\"M40 9H28c-2 0-3 2-3 5v25c0-3 2-5 5-5h10z\"\/><path d=\"M12 16h8m-8 6h8\"\/><\/svg><span>PMC<\/span><\/a><a class=\"cp-source-link cp-source-journal\" href=\"https:\/\/doi.org\/10.1038\/s41598-019-52101-z\" aria-label=\"Open the journal article\" title=\"Open the journal article\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M9 7h20l10 10v24H9z\"\/><path d=\"M29 7v10h10M15 25h18m-18 6h18\"\/><path d=\"M30 22l8-8m-6 0h6v6\"\/><\/svg><span>JOURNAL<\/span><\/a><a class=\"cp-source-link cp-source-pubmed\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31676852\/\" aria-label=\"View the PubMed abstract\" title=\"View the PubMed abstract\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><rect x=\"7\" y=\"8\" width=\"34\" height=\"32\" rx=\"3\"\/><path d=\"M13 16h22M13 23h22M13 30h14\"\/><circle cx=\"34\" cy=\"32\" r=\"4\"\/><\/svg><span>PUBMED<\/span><\/a><\/span><\/p>\n<\/li>\n<li>\n<p class=\"p1\">H.A. Kalpage, A. Vaishnav, J. Liu, A. Varughese, J. Wan, A.A. Turner, Q. Ji, M.P. Zurek, A.A. Kapralov, V.E. Kagan, J.S. Brunzelle, M.A. Recanati, L.I. Grossman, T.H. Sanderson, I. Lee, A.R. Salomon, B.F.P. Edwards, M. H\u00fcttemann. (2019). \u201cSerine-47 phosphorylation of cytochrome c in the mammalian brain regulates cytochrome c oxidase and caspase-3 activity.\u201d <i>FASEB J.<\/i>, 33(12):13503\u201313514. <span class=\"cp-paper-links\" aria-label=\"Publication links\"><a class=\"cp-source-link cp-source-pmc\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6894086\/\" aria-label=\"Read full text in PubMed Central\" title=\"Read full text in PubMed Central\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M8 9h12c3 0 5 2 5 5v25c0-3-2-5-5-5H8z\"\/><path d=\"M40 9H28c-2 0-3 2-3 5v25c0-3 2-5 5-5h10z\"\/><path d=\"M12 16h8m-8 6h8\"\/><\/svg><span>PMC<\/span><\/a><a class=\"cp-source-link cp-source-journal\" href=\"https:\/\/doi.org\/10.1096\/fj.201901120R\" aria-label=\"Open the journal article\" title=\"Open the journal article\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M9 7h20l10 10v24H9z\"\/><path d=\"M29 7v10h10M15 25h18m-18 6h18\"\/><path d=\"M30 22l8-8m-6 0h6v6\"\/><\/svg><span>JOURNAL<\/span><\/a><a class=\"cp-source-link cp-source-pubmed\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31570002\/\" aria-label=\"View the PubMed abstract\" title=\"View the PubMed abstract\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><rect x=\"7\" y=\"8\" width=\"34\" height=\"32\" rx=\"3\"\/><path d=\"M13 16h22M13 23h22M13 30h14\"\/><circle cx=\"34\" cy=\"32\" r=\"4\"\/><\/svg><span>PUBMED<\/span><\/a><\/span><\/p>\n<\/li>\n<li>\n<p class=\"p1\">J. Li, B. Feng, Y. Nie, P. Jiao, X. Lin, M. Huang, R. An, Q. He, H.E. Zhou, A. Salomon, K.S. Sigrist, Z. Wu, S. Liu, H. Xu. (2018). \u201cSucrose nonfermenting-related kinase regulates both adipose inflammation and energy homeostasis in mice and humans.\u201d <i>Diabetes<\/i>, 67(3):400\u2013411. <span class=\"cp-paper-links\" aria-label=\"Publication links\"><a class=\"cp-source-link cp-source-pmc\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC5828454\/\" aria-label=\"Read full text in PubMed Central\" title=\"Read full text in PubMed Central\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M8 9h12c3 0 5 2 5 5v25c0-3-2-5-5-5H8z\"\/><path d=\"M40 9H28c-2 0-3 2-3 5v25c0-3 2-5 5-5h10z\"\/><path d=\"M12 16h8m-8 6h8\"\/><\/svg><span>PMC<\/span><\/a><a class=\"cp-source-link cp-source-journal\" href=\"https:\/\/doi.org\/10.2337\/db17-0745\" aria-label=\"Open the journal article\" title=\"Open the journal article\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M9 7h20l10 10v24H9z\"\/><path d=\"M29 7v10h10M15 25h18m-18 6h18\"\/><path d=\"M30 22l8-8m-6 0h6v6\"\/><\/svg><span>JOURNAL<\/span><\/a><a class=\"cp-source-link cp-source-pubmed\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29298809\/\" aria-label=\"View the PubMed abstract\" title=\"View the PubMed abstract\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><rect x=\"7\" y=\"8\" width=\"34\" height=\"32\" rx=\"3\"\/><path d=\"M13 16h22M13 23h22M13 30h14\"\/><circle cx=\"34\" cy=\"32\" r=\"4\"\/><\/svg><span>PUBMED<\/span><\/a><\/span><\/p>\n<\/li>\n<li>\n<p class=\"p1\">A.O. Adebayo Michael, N. Ahsan, V. Zabala, H. Francois-Vaughan, S. Post, K.E. Brilliant, A.R. Salomon, J.A. Sanders, P.A. Gruppuso. (2017). \u201cProteomic analysis of laser capture microdissected focal lesions in a rat model of progenitor marker-positive hepatocellular carcinoma.\u201d <i>Oncotarget<\/i>, 8(16):26041\u201326056. <span class=\"cp-paper-links\" aria-label=\"Publication links\"><a class=\"cp-source-link cp-source-pmc\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC5432236\/\" aria-label=\"Read full text in PubMed Central\" title=\"Read full text in PubMed Central\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M8 9h12c3 0 5 2 5 5v25c0-3-2-5-5-5H8z\"\/><path d=\"M40 9H28c-2 0-3 2-3 5v25c0-3 2-5 5-5h10z\"\/><path d=\"M12 16h8m-8 6h8\"\/><\/svg><span>PMC<\/span><\/a><a class=\"cp-source-link cp-source-journal\" href=\"https:\/\/doi.org\/10.18632\/oncotarget.15219\" aria-label=\"Open the journal article\" title=\"Open the journal article\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M9 7h20l10 10v24H9z\"\/><path d=\"M29 7v10h10M15 25h18m-18 6h18\"\/><path d=\"M30 22l8-8m-6 0h6v6\"\/><\/svg><span>JOURNAL<\/span><\/a><a class=\"cp-source-link cp-source-pubmed\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28199961\/\" aria-label=\"View the PubMed abstract\" title=\"View the PubMed abstract\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><rect x=\"7\" y=\"8\" width=\"34\" height=\"32\" rx=\"3\"\/><path d=\"M13 16h22M13 23h22M13 30h14\"\/><circle cx=\"34\" cy=\"32\" r=\"4\"\/><\/svg><span>PUBMED<\/span><\/a><\/span><\/p>\n<\/li>\n<li>\n<p class=\"p1\">A. Qadir, P. Ceppi, S. Brockway, C. Law, L. Mu, N. Khodarev, J. Kim, J. Zhao, W. Putzbach, A. Murmann, Z. Chen, W. Chen, X. Liu, A. Salomon, H. Liu, R. Weichselbaum, J. Yu, M. Peter. (2017). \u201cCD95\/Fas increases stemness in cancer cells by inducing a STAT1-dependent type I interferon response.\u201d <i>Cell Rep.<\/i>, 18(10):2373\u20132386. <span class=\"cp-paper-links\" aria-label=\"Publication links\"><a class=\"cp-source-link cp-source-pmc\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC5474321\/\" aria-label=\"Read full text in PubMed Central\" title=\"Read full text in PubMed Central\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M8 9h12c3 0 5 2 5 5v25c0-3-2-5-5-5H8z\"\/><path d=\"M40 9H28c-2 0-3 2-3 5v25c0-3 2-5 5-5h10z\"\/><path d=\"M12 16h8m-8 6h8\"\/><\/svg><span>PMC<\/span><\/a><a class=\"cp-source-link cp-source-journal\" href=\"https:\/\/doi.org\/10.1016\/j.celrep.2017.02.037\" aria-label=\"Open the journal article\" title=\"Open the journal article\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M9 7h20l10 10v24H9z\"\/><path d=\"M29 7v10h10M15 25h18m-18 6h18\"\/><path d=\"M30 22l8-8m-6 0h6v6\"\/><\/svg><span>JOURNAL<\/span><\/a><a class=\"cp-source-link cp-source-pubmed\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28273453\/\" aria-label=\"View the PubMed abstract\" title=\"View the PubMed abstract\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><rect x=\"7\" y=\"8\" width=\"34\" height=\"32\" rx=\"3\"\/><path d=\"M13 16h22M13 23h22M13 30h14\"\/><circle cx=\"34\" cy=\"32\" r=\"4\"\/><\/svg><span>PUBMED<\/span><\/a><\/span><\/p>\n<\/li>\n<li>\n<p class=\"p1\">G. Mahapatra, A. Varughese, Q. Ji, I. Lee, J. Liu, A. Vaishnav, C. Sinkler, A.A. Kapralov, C.T. Moraes, T.H. Sanderson, T.L. Stemmler, L.I. Grossman, V.E. Kagan, J.S. Brunzelle, A.R. Salomon, B.F. Edwards, M. H\u00fcttemann. (2017). \u201cPhosphorylation of cytochrome c threonine 28 regulates electron transport chain activity in kidney: implications for AMP kinase.\u201d <i>J. Biol. Chem.<\/i>, 292(1):64\u201379. <span class=\"cp-paper-links\" aria-label=\"Publication links\"><a class=\"cp-source-link cp-source-pmc\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC5217700\/\" aria-label=\"Read full text in PubMed Central\" title=\"Read full text in PubMed Central\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M8 9h12c3 0 5 2 5 5v25c0-3-2-5-5-5H8z\"\/><path d=\"M40 9H28c-2 0-3 2-3 5v25c0-3 2-5 5-5h10z\"\/><path d=\"M12 16h8m-8 6h8\"\/><\/svg><span>PMC<\/span><\/a><a class=\"cp-source-link cp-source-journal\" href=\"https:\/\/doi.org\/10.1074\/jbc.M116.744664\" aria-label=\"Open the journal article\" title=\"Open the journal article\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M9 7h20l10 10v24H9z\"\/><path d=\"M29 7v10h10M15 25h18m-18 6h18\"\/><path d=\"M30 22l8-8m-6 0h6v6\"\/><\/svg><span>JOURNAL<\/span><\/a><a class=\"cp-source-link cp-source-pubmed\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27758862\/\" aria-label=\"View the PubMed abstract\" title=\"View the PubMed abstract\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><rect x=\"7\" y=\"8\" width=\"34\" height=\"32\" rx=\"3\"\/><path d=\"M13 16h22M13 23h22M13 30h14\"\/><circle cx=\"34\" cy=\"32\" r=\"4\"\/><\/svg><span>PUBMED<\/span><\/a><\/span><\/p>\n<\/li>\n<li>\n<p class=\"p1\">J.M. Boylan, A.R. Salomon, U. Tantravahi, P.A. Gruppuso. (2015). \u201cAdaptation of HepG2 cells to a steady-state reduction in the content of protein phosphatase 6 (PP6) catalytic subunit.\u201d <i>Exp. Cell Res.<\/i>, 335(2):224\u2013237. <span class=\"cp-paper-links\" aria-label=\"Publication links\"><a class=\"cp-source-link cp-source-pmc\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4485549\/\" aria-label=\"Read full text in PubMed Central\" title=\"Read full text in PubMed Central\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M8 9h12c3 0 5 2 5 5v25c0-3-2-5-5-5H8z\"\/><path d=\"M40 9H28c-2 0-3 2-3 5v25c0-3 2-5 5-5h10z\"\/><path d=\"M12 16h8m-8 6h8\"\/><\/svg><span>PMC<\/span><\/a><a class=\"cp-source-link cp-source-journal\" href=\"https:\/\/doi.org\/10.1016\/j.yexcr.2015.05.008\" aria-label=\"Open the journal article\" title=\"Open the journal article\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M9 7h20l10 10v24H9z\"\/><path d=\"M29 7v10h10M15 25h18m-18 6h18\"\/><path d=\"M30 22l8-8m-6 0h6v6\"\/><\/svg><span>JOURNAL<\/span><\/a><a class=\"cp-source-link cp-source-pubmed\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25999147\/\" aria-label=\"View the PubMed abstract\" title=\"View the PubMed abstract\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><rect x=\"7\" y=\"8\" width=\"34\" height=\"32\" rx=\"3\"\/><path d=\"M13 16h22M13 23h22M13 30h14\"\/><circle cx=\"34\" cy=\"32\" r=\"4\"\/><\/svg><span>PUBMED<\/span><\/a><\/span><\/p>\n<\/li>\n<li>\n<p class=\"p1\">W. Wimuttisuk, M. West, B. Davidge, K. Yu, A. Salomon, J.D. Singer. (2014). \u201cNovel Cul3 binding proteins function to remodel E3 ligase complexes.\u201d <i>BMC Cell Biol.<\/i>, 15:28. <span class=\"cp-paper-links\" aria-label=\"Publication links\"><a class=\"cp-source-link cp-source-pmc\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4107866\/\" aria-label=\"Read full text in PubMed Central\" title=\"Read full text in PubMed Central\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M8 9h12c3 0 5 2 5 5v25c0-3-2-5-5-5H8z\"\/><path d=\"M40 9H28c-2 0-3 2-3 5v25c0-3 2-5 5-5h10z\"\/><path d=\"M12 16h8m-8 6h8\"\/><\/svg><span>PMC<\/span><\/a><a class=\"cp-source-link cp-source-journal\" href=\"https:\/\/doi.org\/10.1186\/1471-2121-15-28\" aria-label=\"Open the journal article\" title=\"Open the journal article\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M9 7h20l10 10v24H9z\"\/><path d=\"M29 7v10h10M15 25h18m-18 6h18\"\/><path d=\"M30 22l8-8m-6 0h6v6\"\/><\/svg><span>JOURNAL<\/span><\/a><a class=\"cp-source-link cp-source-pubmed\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25011449\/\" aria-label=\"View the PubMed abstract\" title=\"View the PubMed abstract\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><rect x=\"7\" y=\"8\" width=\"34\" height=\"32\" rx=\"3\"\/><path d=\"M13 16h22M13 23h22M13 30h14\"\/><circle cx=\"34\" cy=\"32\" r=\"4\"\/><\/svg><span>PUBMED<\/span><\/a><\/span><\/p>\n<\/li>\n<li>\n<p class=\"p1\">B. Feng, P. Jiao, Y. Helou, Y. Li, Q. He, M.S. Walters, A. Salomon, H. Xu. (2014). \u201cMitogen-activated protein kinase phosphatase 3 (MKP-3)-deficient mice are resistant to diet-induced obesity.\u201d <i>Diabetes<\/i>, 63(9):2924\u20132934. <span class=\"cp-paper-links\" aria-label=\"Publication links\"><a class=\"cp-source-link cp-source-pmc\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4141371\/\" aria-label=\"Read full text in PubMed Central\" title=\"Read full text in PubMed Central\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M8 9h12c3 0 5 2 5 5v25c0-3-2-5-5-5H8z\"\/><path d=\"M40 9H28c-2 0-3 2-3 5v25c0-3 2-5 5-5h10z\"\/><path d=\"M12 16h8m-8 6h8\"\/><\/svg><span>PMC<\/span><\/a><a class=\"cp-source-link cp-source-journal\" href=\"https:\/\/doi.org\/10.2337\/db14-0066\" aria-label=\"Open the journal article\" title=\"Open the journal article\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M9 7h20l10 10v24H9z\"\/><path d=\"M29 7v10h10M15 25h18m-18 6h18\"\/><path d=\"M30 22l8-8m-6 0h6v6\"\/><\/svg><span>JOURNAL<\/span><\/a><a class=\"cp-source-link cp-source-pubmed\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24722245\/\" aria-label=\"View the PubMed abstract\" title=\"View the PubMed abstract\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><rect x=\"7\" y=\"8\" width=\"34\" height=\"32\" rx=\"3\"\/><path d=\"M13 16h22M13 23h22M13 30h14\"\/><circle cx=\"34\" cy=\"32\" r=\"4\"\/><\/svg><span>PUBMED<\/span><\/a><\/span><\/p>\n<\/li>\n<li>\n<p class=\"p1\">B.D. DeNardo, M.P. Holloway, Q. Ji, K.T. Nguyen, Y. Cheng, M.B. Valentine, A. Salomon, R.A. Altura. (2013). \u201cQuantitative phosphoproteomic analysis identifies activation of the RET and IGF-1R\/IR signaling pathways in neuroblastoma.\u201d <i>PLoS One<\/i>, 8(12):e82513. <span class=\"cp-paper-links\" aria-label=\"Publication links\"><a class=\"cp-source-link cp-source-pmc\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3859635\/\" aria-label=\"Read full text in PubMed Central\" title=\"Read full text in PubMed Central\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M8 9h12c3 0 5 2 5 5v25c0-3-2-5-5-5H8z\"\/><path d=\"M40 9H28c-2 0-3 2-3 5v25c0-3 2-5 5-5h10z\"\/><path d=\"M12 16h8m-8 6h8\"\/><\/svg><span>PMC<\/span><\/a><a class=\"cp-source-link cp-source-journal\" href=\"https:\/\/doi.org\/10.1371\/journal.pone.0082513\" aria-label=\"Open the journal article\" title=\"Open the journal article\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M9 7h20l10 10v24H9z\"\/><path d=\"M29 7v10h10M15 25h18m-18 6h18\"\/><path d=\"M30 22l8-8m-6 0h6v6\"\/><\/svg><span>JOURNAL<\/span><\/a><a class=\"cp-source-link cp-source-pubmed\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24349301\/\" aria-label=\"View the PubMed abstract\" title=\"View the PubMed abstract\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><rect x=\"7\" y=\"8\" width=\"34\" height=\"32\" rx=\"3\"\/><path d=\"M13 16h22M13 23h22M13 30h14\"\/><circle cx=\"34\" cy=\"32\" r=\"4\"\/><\/svg><span>PUBMED<\/span><\/a><\/span><\/p>\n<\/li>\n<li>\n<p class=\"p1\">T.H. Sanderson, G. Mahapatra, P. Pecina, Q. Ji, K. Yu, C. Sinkler, A. Varughese, R. Kumar, M.J. Bukowski, R.N. Tousignant, A.R. Salomon, I. Lee, M. H\u00fcttemann. (2013). \u201cCytochrome c is tyrosine 97 phosphorylated by neuroprotective insulin treatment.\u201d <i>PLoS One<\/i>, 8(11):e78627. <span class=\"cp-paper-links\" aria-label=\"Publication links\"><a class=\"cp-source-link cp-source-pmc\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3818486\/\" aria-label=\"Read full text in PubMed Central\" title=\"Read full text in PubMed Central\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M8 9h12c3 0 5 2 5 5v25c0-3-2-5-5-5H8z\"\/><path d=\"M40 9H28c-2 0-3 2-3 5v25c0-3 2-5 5-5h10z\"\/><path d=\"M12 16h8m-8 6h8\"\/><\/svg><span>PMC<\/span><\/a><a class=\"cp-source-link cp-source-journal\" href=\"https:\/\/doi.org\/10.1371\/journal.pone.0078627\" aria-label=\"Open the journal article\" title=\"Open the journal article\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M9 7h20l10 10v24H9z\"\/><path d=\"M29 7v10h10M15 25h18m-18 6h18\"\/><path d=\"M30 22l8-8m-6 0h6v6\"\/><\/svg><span>JOURNAL<\/span><\/a><a class=\"cp-source-link cp-source-pubmed\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24223835\/\" aria-label=\"View the PubMed abstract\" title=\"View the PubMed abstract\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><rect x=\"7\" y=\"8\" width=\"34\" height=\"32\" rx=\"3\"\/><path d=\"M13 16h22M13 23h22M13 30h14\"\/><circle cx=\"34\" cy=\"32\" r=\"4\"\/><\/svg><span>PUBMED<\/span><\/a><\/span><\/p>\n<\/li>\n<li>\n<p class=\"p1\">D.W. Lamming, G. Demirkan, J.M. Boylan, M.M. Mihaylova, T. Peng, J. Ferreira, N. Neretti, A. Salomon, D.M. Sabatini, P.A. Gruppuso. (2014). \u201cHepatic signaling by the mechanistic target of rapamycin complex 2 (mTORC2).\u201d <i>FASEB J.<\/i>, 28(1):300\u2013315. <span class=\"cp-paper-links\" aria-label=\"Publication links\"><a class=\"cp-source-link cp-source-pmc\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3868844\/\" aria-label=\"Read full text in PubMed Central\" title=\"Read full text in PubMed Central\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M8 9h12c3 0 5 2 5 5v25c0-3-2-5-5-5H8z\"\/><path d=\"M40 9H28c-2 0-3 2-3 5v25c0-3 2-5 5-5h10z\"\/><path d=\"M12 16h8m-8 6h8\"\/><\/svg><span>PMC<\/span><\/a><a class=\"cp-source-link cp-source-journal\" href=\"https:\/\/doi.org\/10.1096\/fj.13-237743\" aria-label=\"Open the journal article\" title=\"Open the journal article\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M9 7h20l10 10v24H9z\"\/><path d=\"M29 7v10h10M15 25h18m-18 6h18\"\/><path d=\"M30 22l8-8m-6 0h6v6\"\/><\/svg><span>JOURNAL<\/span><\/a><a class=\"cp-source-link cp-source-pubmed\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24072782\/\" aria-label=\"View the PubMed abstract\" title=\"View the PubMed abstract\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><rect x=\"7\" y=\"8\" width=\"34\" height=\"32\" rx=\"3\"\/><path d=\"M13 16h22M13 23h22M13 30h14\"\/><circle cx=\"34\" cy=\"32\" r=\"4\"\/><\/svg><span>PUBMED<\/span><\/a><\/span><\/p>\n<\/li>\n<li>\n<p class=\"p1\">Y. Li, Y. Nie, Y. Helou, G. Ding, B. Feng, H. Xu, A. Salomon, H. Xu. (2013). \u201cIdentification of sucrose non-fermenting-related kinase (SNRK) as a suppressor of adipocyte inflammation.\u201d <i>Diabetes<\/i>, 62(7):2396\u20132409. <span class=\"cp-paper-links\" aria-label=\"Publication links\"><a class=\"cp-source-link cp-source-pmc\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3712026\/\" aria-label=\"Read full text in PubMed Central\" title=\"Read full text in PubMed Central\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M8 9h12c3 0 5 2 5 5v25c0-3-2-5-5-5H8z\"\/><path d=\"M40 9H28c-2 0-3 2-3 5v25c0-3 2-5 5-5h10z\"\/><path d=\"M12 16h8m-8 6h8\"\/><\/svg><span>PMC<\/span><\/a><a class=\"cp-source-link cp-source-journal\" href=\"https:\/\/doi.org\/10.2337\/db12-1081\" aria-label=\"Open the journal article\" title=\"Open the journal article\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M9 7h20l10 10v24H9z\"\/><path d=\"M29 7v10h10M15 25h18m-18 6h18\"\/><path d=\"M30 22l8-8m-6 0h6v6\"\/><\/svg><span>JOURNAL<\/span><\/a><a class=\"cp-source-link cp-source-pubmed\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23520131\/\" aria-label=\"View the PubMed abstract\" title=\"View the PubMed abstract\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><rect x=\"7\" y=\"8\" width=\"34\" height=\"32\" rx=\"3\"\/><path d=\"M13 16h22M13 23h22M13 30h14\"\/><circle cx=\"34\" cy=\"32\" r=\"4\"\/><\/svg><span>PUBMED<\/span><\/a><\/span><\/p>\n<\/li>\n<li>\n<p class=\"p1\">G. Demirkan, A.R. Salomon, P.A. Gruppuso. (2012). \u201cPhosphoproteomic analysis of liver homogenates.\u201d <i>Methods Mol. Biol.<\/i>, 909:151\u2013163. <span class=\"cp-paper-links\" aria-label=\"Publication links\"><a class=\"cp-source-link cp-source-pmc\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3581044\/\" aria-label=\"Read full text in PubMed Central\" title=\"Read full text in PubMed Central\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M8 9h12c3 0 5 2 5 5v25c0-3-2-5-5-5H8z\"\/><path d=\"M40 9H28c-2 0-3 2-3 5v25c0-3 2-5 5-5h10z\"\/><path d=\"M12 16h8m-8 6h8\"\/><\/svg><span>PMC<\/span><\/a><a class=\"cp-source-link cp-source-journal\" href=\"https:\/\/doi.org\/10.1007\/978-1-61779-959-4_11\" aria-label=\"Open the journal article\" title=\"Open the journal article\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M9 7h20l10 10v24H9z\"\/><path d=\"M29 7v10h10M15 25h18m-18 6h18\"\/><path d=\"M30 22l8-8m-6 0h6v6\"\/><\/svg><span>JOURNAL<\/span><\/a><a class=\"cp-source-link cp-source-pubmed\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22903715\/\" aria-label=\"View the PubMed abstract\" title=\"View the PubMed abstract\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><rect x=\"7\" y=\"8\" width=\"34\" height=\"32\" rx=\"3\"\/><path d=\"M13 16h22M13 23h22M13 30h14\"\/><circle cx=\"34\" cy=\"32\" r=\"4\"\/><\/svg><span>PUBMED<\/span><\/a><\/span><\/p>\n<\/li>\n<li>\n<p class=\"p1\">X.M. O\u2019Brien, K.E. Heflin, L.M. Lavigne, K. Yu, M. Kim, A.R. Salomon, J.S. Reichner. (2012). \u201cLectin site ligation of CR3 induces conformational changes and signaling.\u201d <i>J. Biol. Chem.<\/i>, 287(5):3337\u20133348. <span class=\"cp-paper-links\" aria-label=\"Publication links\"><a class=\"cp-source-link cp-source-pmc\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3270988\/\" aria-label=\"Read full text in PubMed Central\" title=\"Read full text in PubMed Central\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M8 9h12c3 0 5 2 5 5v25c0-3-2-5-5-5H8z\"\/><path d=\"M40 9H28c-2 0-3 2-3 5v25c0-3 2-5 5-5h10z\"\/><path d=\"M12 16h8m-8 6h8\"\/><\/svg><span>PMC<\/span><\/a><a class=\"cp-source-link cp-source-journal\" href=\"https:\/\/doi.org\/10.1074\/jbc.M111.298307\" aria-label=\"Open the journal article\" title=\"Open the journal article\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M9 7h20l10 10v24H9z\"\/><path d=\"M29 7v10h10M15 25h18m-18 6h18\"\/><path d=\"M30 22l8-8m-6 0h6v6\"\/><\/svg><span>JOURNAL<\/span><\/a><a class=\"cp-source-link cp-source-pubmed\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22158618\/\" aria-label=\"View the PubMed abstract\" title=\"View the PubMed abstract\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><rect x=\"7\" y=\"8\" width=\"34\" height=\"32\" rx=\"3\"\/><path d=\"M13 16h22M13 23h22M13 30h14\"\/><circle cx=\"34\" cy=\"32\" r=\"4\"\/><\/svg><span>PUBMED<\/span><\/a><\/span><\/p>\n<\/li>\n<li>\n<p class=\"p1\">G. Demirkan, K. Yu, J.M. Boylan, A.R. Salomon, P.A. Gruppuso. (2011). \u201cPhosphoproteomic profiling of in vivo signaling in liver by the mammalian target of rapamycin complex 1 (mTORC1).\u201d <i>PLoS One<\/i>, 6(6):e21729. <span class=\"cp-paper-links\" aria-label=\"Publication links\"><a class=\"cp-source-link cp-source-pmc\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3125343\/\" aria-label=\"Read full text in PubMed Central\" title=\"Read full text in PubMed Central\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M8 9h12c3 0 5 2 5 5v25c0-3-2-5-5-5H8z\"\/><path d=\"M40 9H28c-2 0-3 2-3 5v25c0-3 2-5 5-5h10z\"\/><path d=\"M12 16h8m-8 6h8\"\/><\/svg><span>PMC<\/span><\/a><a class=\"cp-source-link cp-source-journal\" href=\"https:\/\/doi.org\/10.1371\/journal.pone.0021729\" aria-label=\"Open the journal article\" title=\"Open the journal article\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M9 7h20l10 10v24H9z\"\/><path d=\"M29 7v10h10M15 25h18m-18 6h18\"\/><path d=\"M30 22l8-8m-6 0h6v6\"\/><\/svg><span>JOURNAL<\/span><\/a><a class=\"cp-source-link cp-source-pubmed\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21738781\/\" aria-label=\"View the PubMed abstract\" title=\"View the PubMed abstract\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><rect x=\"7\" y=\"8\" width=\"34\" height=\"32\" rx=\"3\"\/><path d=\"M13 16h22M13 23h22M13 30h14\"\/><circle cx=\"34\" cy=\"32\" r=\"4\"\/><\/svg><span>PUBMED<\/span><\/a><\/span><\/p>\n<\/li>\n<li>\n<p class=\"p1\">P. Agrawal, K. Yu, A.R. Salomon, J.M. Sedivy. (2010). \u201cProteomic profiling of Myc-associated proteins.\u201d <i>Cell Cycle<\/i>, 9(24):4908\u20134921. <span class=\"cp-paper-links\" aria-label=\"Publication links\"><a class=\"cp-source-link cp-source-pmc\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3047814\/\" aria-label=\"Read full text in PubMed Central\" title=\"Read full text in PubMed Central\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M8 9h12c3 0 5 2 5 5v25c0-3-2-5-5-5H8z\"\/><path d=\"M40 9H28c-2 0-3 2-3 5v25c0-3 2-5 5-5h10z\"\/><path d=\"M12 16h8m-8 6h8\"\/><\/svg><span>PMC<\/span><\/a><a class=\"cp-source-link cp-source-journal\" href=\"https:\/\/doi.org\/10.4161\/cc.9.24.14199\" aria-label=\"Open the journal article\" title=\"Open the journal article\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M9 7h20l10 10v24H9z\"\/><path d=\"M29 7v10h10M15 25h18m-18 6h18\"\/><path d=\"M30 22l8-8m-6 0h6v6\"\/><\/svg><span>JOURNAL<\/span><\/a><a class=\"cp-source-link cp-source-pubmed\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21150319\/\" aria-label=\"View the PubMed abstract\" title=\"View the PubMed abstract\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><rect x=\"7\" y=\"8\" width=\"34\" height=\"32\" rx=\"3\"\/><path d=\"M13 16h22M13 23h22M13 30h14\"\/><circle cx=\"34\" cy=\"32\" r=\"4\"\/><\/svg><span>PUBMED<\/span><\/a><\/span><\/p>\n<\/li>\n<li>\n<p class=\"p1\">J.A. Pezza, S.X. Langseth, R. Raupp Yamamoto, S.M. Doris, S.P. Ulin, A.R. Salomon, T.R. Serio. (2009). \u201cThe NatA acetyltransferase couples Sup35 prion complexes to the [PSI+] phenotype.\u201d <i>Mol. Biol. Cell<\/i>, 20(3):1068\u20131080. <span class=\"cp-paper-links\" aria-label=\"Publication links\"><a class=\"cp-source-link cp-source-pmc\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC2633373\/\" aria-label=\"Read full text in PubMed Central\" title=\"Read full text in PubMed Central\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M8 9h12c3 0 5 2 5 5v25c0-3-2-5-5-5H8z\"\/><path d=\"M40 9H28c-2 0-3 2-3 5v25c0-3 2-5 5-5h10z\"\/><path d=\"M12 16h8m-8 6h8\"\/><\/svg><span>PMC<\/span><\/a><a class=\"cp-source-link cp-source-journal\" href=\"https:\/\/doi.org\/10.1091\/mbc.E08-04-0436\" aria-label=\"Open the journal article\" title=\"Open the journal article\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M9 7h20l10 10v24H9z\"\/><path d=\"M29 7v10h10M15 25h18m-18 6h18\"\/><path d=\"M30 22l8-8m-6 0h6v6\"\/><\/svg><span>JOURNAL<\/span><\/a><a class=\"cp-source-link cp-source-pubmed\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19073888\/\" aria-label=\"View the PubMed abstract\" title=\"View the PubMed abstract\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><rect x=\"7\" y=\"8\" width=\"34\" height=\"32\" rx=\"3\"\/><path d=\"M13 16h22M13 23h22M13 30h14\"\/><circle cx=\"34\" cy=\"32\" r=\"4\"\/><\/svg><span>PUBMED<\/span><\/a><\/span><\/p>\n<\/li>\n<li>\n<p class=\"p1\">H. Yu, I. Lee, A.R. Salomon, K. Yu, M. H\u00fcttemann. (2008). \u201cMammalian liver cytochrome c is tyrosine-48 phosphorylated in vivo, inhibiting mitochondrial respiration.\u201d <i>Biochim. Biophys. Acta<\/i>, 1777(7\u20138):1066\u20131071. <span class=\"cp-paper-links\" aria-label=\"Publication links\"><a class=\"cp-source-link cp-source-pmc\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC2652845\/\" aria-label=\"Read full text in PubMed Central\" title=\"Read full text in PubMed Central\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M8 9h12c3 0 5 2 5 5v25c0-3-2-5-5-5H8z\"\/><path d=\"M40 9H28c-2 0-3 2-3 5v25c0-3 2-5 5-5h10z\"\/><path d=\"M12 16h8m-8 6h8\"\/><\/svg><span>PMC<\/span><\/a><a class=\"cp-source-link cp-source-journal\" href=\"https:\/\/doi.org\/10.1016\/j.bbabio.2008.04.023\" aria-label=\"Open the journal article\" title=\"Open the journal article\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M9 7h20l10 10v24H9z\"\/><path d=\"M29 7v10h10M15 25h18m-18 6h18\"\/><path d=\"M30 22l8-8m-6 0h6v6\"\/><\/svg><span>JOURNAL<\/span><\/a><a class=\"cp-source-link cp-source-pubmed\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18471988\/\" aria-label=\"View the PubMed abstract\" title=\"View the PubMed abstract\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><rect x=\"7\" y=\"8\" width=\"34\" height=\"32\" rx=\"3\"\/><path d=\"M13 16h22M13 23h22M13 30h14\"\/><circle cx=\"34\" cy=\"32\" r=\"4\"\/><\/svg><span>PUBMED<\/span><\/a><\/span><\/p>\n<\/li>\n<li>\n<p class=\"p1\">I. Lee, A.R. Salomon, J.W. Doan, L.I. Grossman, M. H\u00fcttemann. (2006). \u201cNew prospects for an old enzyme: mammalian cytochrome c is tyrosine-phosphorylated in vivo.\u201d <i>Biochemistry<\/i>, 45(30):9121\u20139128.. <span class=\"cp-paper-links\" aria-label=\"Publication links\"><a class=\"cp-source-link cp-source-journal\" href=\"https:\/\/doi.org\/10.1021\/bi060585v\" aria-label=\"Open the journal article\" title=\"Open the journal article\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M9 7h20l10 10v24H9z\"\/><path d=\"M29 7v10h10M15 25h18m-18 6h18\"\/><path d=\"M30 22l8-8m-6 0h6v6\"\/><\/svg><span>JOURNAL<\/span><\/a><a class=\"cp-source-link cp-source-pubmed\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16866357\/\" aria-label=\"View the PubMed abstract\" title=\"View the PubMed abstract\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><rect x=\"7\" y=\"8\" width=\"34\" height=\"32\" rx=\"3\"\/><path d=\"M13 16h22M13 23h22M13 30h14\"\/><circle cx=\"34\" cy=\"32\" r=\"4\"\/><\/svg><span>PUBMED<\/span><\/a><\/span><\/p>\n<\/li>\n<li>\n<p class=\"p1\">I. Lee, A.R. Salomon, S. Ficarro, I. Mathes, F. Lottspeich, L.I. Grossman, M. H\u00fcttemann. (2005). \u201ccAMP-dependent tyrosine phosphorylation of subunit I inhibits cytochrome c oxidase activity.\u201d <i>J. Biol. Chem.<\/i>, 280(7):6094\u20136100.. <span class=\"cp-paper-links\" aria-label=\"Publication links\"><a class=\"cp-source-link cp-source-journal\" href=\"https:\/\/doi.org\/10.1074\/jbc.m411335200\" aria-label=\"Open the journal article\" title=\"Open the journal article\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M9 7h20l10 10v24H9z\"\/><path d=\"M29 7v10h10M15 25h18m-18 6h18\"\/><path d=\"M30 22l8-8m-6 0h6v6\"\/><\/svg><span>JOURNAL<\/span><\/a><a class=\"cp-source-link cp-source-pubmed\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15557277\/\" aria-label=\"View the PubMed abstract\" title=\"View the PubMed abstract\" target=\"_blank\" rel=\"noopener noreferrer\"><svg viewBox=\"0 0 48 48\" aria-hidden=\"true\" focusable=\"false\"><rect x=\"7\" y=\"8\" width=\"34\" height=\"32\" rx=\"3\"\/><path d=\"M13 16h22M13 23h22M13 30h14\"\/><circle cx=\"34\" cy=\"32\" r=\"4\"\/><\/svg><span>PUBMED<\/span><\/a><\/span><\/p>\n<\/li>\n<\/ol>\n<\/div>\n<div style=\"width: 100%; background: #eeeeee; padding: 5px 0 5px 5px;\"><\/div>\n<\/p><\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Salomon Laboratory \u00b7 Brown University Decoding cellular signals to advance human health We combine quantitative phosphoproteomics, immune-cell biology, and computational analysis to reveal how signaling networks control T cells, cancer, and disease. Receptor Network LC\u2013MS Insight CAR T signaling TCR networks Phosphoproteomics Computational platforms Human disease Introduction Our lab research centers on cellular signaling and&hellip; <a class=\"continue\" href=\"https:\/\/cellpathway.com\/?page_id=5\">Continue Reading<span> Research<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":1,"comment_status":"closed","ping_status":"open","template":"","meta":{"footnotes":""},"class_list":["post-5","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/cellpathway.com\/index.php?rest_route=\/wp\/v2\/pages\/5","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cellpathway.com\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/cellpathway.com\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/cellpathway.com\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/cellpathway.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=5"}],"version-history":[{"count":86,"href":"https:\/\/cellpathway.com\/index.php?rest_route=\/wp\/v2\/pages\/5\/revisions"}],"predecessor-version":[{"id":958,"href":"https:\/\/cellpathway.com\/index.php?rest_route=\/wp\/v2\/pages\/5\/revisions\/958"}],"wp:attachment":[{"href":"https:\/\/cellpathway.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=5"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}