{"id":2,"date":"2010-08-26T16:33:59","date_gmt":"2010-08-26T16:33:59","guid":{"rendered":"https:\/\/cellpathway.com\/?page_id=2"},"modified":"2026-08-15T14:05:28","modified_gmt":"2026-08-15T18:05:28","slug":"about","status":"publish","type":"page","link":"https:\/\/cellpathway.com\/","title":{"rendered":"Welcome to the Salomon Research Group"},"content":{"rendered":"<section class=\"cp-welcome-overview\" aria-labelledby=\"cp-welcome-big-picture\">\n<p class=\"cp-welcome-eyebrow\">Welcome to the Salomon Laboratory<\/p>\n<h1 id=\"cp-welcome-big-picture\">Decoding how molecular networks shape immune-cell responses.<\/h1>\n<p class=\"cp-welcome-lead\">Immune cells must decide when to respond, how strongly to act, and when to stop. The Salomon Laboratory studies the molecular messages that guide those choices, both in natural immune responses and in engineered cell therapies. By combining advanced mass spectrometry, biochemistry, and computational analysis, we can measure thousands of signaling changes at once and discover how they work together to shape what cells ultimately do.<\/p>\n<figure class=\"cp-welcome-frontier-art\" aria-labelledby=\"cp-welcome-frontier-caption\">\n    <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/cellpathway.com\/wp-content\/uploads\/2026\/08\/engineered-contact-target-activation-banner.jpg\" width=\"1600\" height=\"356\" alt=\"Conceptual illustration of an engineered immune cell contacting a target cell, activating a molecular network inside it, followed by target-cell multiplication.\"><figcaption id=\"cp-welcome-frontier-caption\"><strong>A current frontier:<\/strong> understanding both sides of engineered immune-cell contact.<\/figcaption><\/figure>\n<p class=\"cp-welcome-lead cp-welcome-lead-lab\">One current focus asks how a target cell interprets contact with an engineered immune cell. Because receptors used for recognition can themselves signal, the target may grow, survive, or be eliminated. Cell-of-origin phosphoproteomics lets us resolve both sides of the interaction and connect molecular mechanisms with biological outcomes.<\/p>\n<ul class=\"cp-welcome-path\" aria-label=\"Research themes across our program\">\n<li>\n      <span class=\"cp-welcome-icon\" aria-hidden=\"true\"><svg viewBox=\"0 0 48 48\" focusable=\"false\"><path d=\"M8 15h12l4 7 4-7h12M8 33h12l4-7 4 7h12\"\/><circle cx=\"8\" cy=\"15\" r=\"3\"\/><circle cx=\"40\" cy=\"15\" r=\"3\"\/><circle cx=\"8\" cy=\"33\" r=\"3\"\/><circle cx=\"40\" cy=\"33\" r=\"3\"\/><\/svg><\/span><\/p>\n<h2>What controls immune-cell decisions?<\/h2>\n<p>We define how receptors, kinases, phosphatases, feedback, and pathway crosstalk organize signaling responses.<\/p>\n<\/li>\n<li>\n      <span class=\"cp-welcome-icon\" aria-hidden=\"true\"><svg viewBox=\"0 0 48 48\" focusable=\"false\"><circle cx=\"15\" cy=\"24\" r=\"9\"\/><circle cx=\"34\" cy=\"24\" r=\"9\"\/><path d=\"M24 20l5-4m-5 12l5 4M19 18l5 2v8l-5 2\"\/><circle cx=\"13\" cy=\"21\" r=\"1.5\"\/><circle cx=\"13\" cy=\"27\" r=\"1.5\"\/><circle cx=\"36\" cy=\"21\" r=\"1.5\"\/><circle cx=\"36\" cy=\"27\" r=\"1.5\"\/><\/svg><\/span><\/p>\n<h2>How do interacting cells respond?<\/h2>\n<p>We resolve molecular responses from each cell type in mixed cocultures, exposing changes hidden in the combined sample.<\/p>\n<\/li>\n<li>\n      <span class=\"cp-welcome-icon\" aria-hidden=\"true\"><svg viewBox=\"0 0 48 48\" focusable=\"false\"><path d=\"M8 38h32M12 34V24m8 10V12m8 22V20m8 14V8\"\/><path d=\"M11 18l8-7 8 5 9-10\"\/><circle cx=\"11\" cy=\"18\" r=\"2\"\/><circle cx=\"19\" cy=\"11\" r=\"2\"\/><circle cx=\"27\" cy=\"16\" r=\"2\"\/><circle cx=\"36\" cy=\"6\" r=\"2\"\/><\/svg><\/span><\/p>\n<h2>Which mechanisms shape outcomes?<\/h2>\n<p>We connect quantitative phosphorylation networks with biochemical mechanisms and cellular outcomes.<\/p>\n<\/li>\n<\/ul>\n<p class=\"cp-welcome-action\">\n    <a href=\"https:\/\/cellpathway.com\/?page_id=5\">Explore our research<\/a><br \/>\n    <a class=\"cp-welcome-jump\" href=\"#cp-latest-result\">Jump to latest result<\/a>\n  <\/p>\n<\/section>\n<section id=\"cp-latest-result\" class=\"cp-latest-result\" tabindex=\"-1\" aria-labelledby=\"cp-latest-result-title\">\n<div class=\"cp-latest-result-copy\">\n<p class=\"cp-welcome-eyebrow\">Latest published discovery <span aria-hidden=\"true\">&#183;<\/span> Science Signaling<\/p>\n<h2 id=\"cp-latest-result-title\">CAR target cells are active participants<\/h2>\n<p>Most CAR studies ask what the engineered T cell does. Our recent study asks what happens inside the contacted target cell. Cell-of-origin phosphotyrosine proteomics shows that a CSF1R-directed CAR triggers CSF1R-like signaling in THP-1 target cells, whereas CD19-CAR contact does not produce the same signaling response in Raji targets.<\/p>\n<aside class=\"cp-latest-result-implication\" aria-labelledby=\"cp-rtk-implication-title\">\n<h3 id=\"cp-rtk-implication-title\">Why this matters for solid tumors<\/h3>\n<p>Receptor tyrosine kinases are attractive CAR targets in solid tumors, but extending CAR T-cell success beyond blood cancers remains a critical challenge. The CSF1R result shows why the target itself must be studied: CAR engagement of an RTK can trigger target-cell signaling and, in this model, support target-cell growth when targets outnumber effectors. Measuring both sides of the interaction may help guide antigen selection and the design of RTK-directed CAR therapies.<\/p>\n<\/aside>\n<ul class=\"cp-latest-result-points\">\n<li><strong>The target signals:<\/strong> CSF1R Tyr723 and downstream ERK phosphorylation increase after CSF1R-CAR contact.<\/li>\n<li><strong>The mechanism is target-cell intrinsic:<\/strong> the response requires CSF1R kinase activity but not T-cell Lck activity or actin polymerization.<\/li>\n<li><strong>Cell ratio changes the outcome:<\/strong> target-rich conditions promote THP-1 growth, whereas effector-rich conditions produce target-cell lysis.<\/li>\n<\/ul>\n<p class=\"cp-latest-result-links\">\n      <a href=\"https:\/\/www.science.org\/doi\/10.1126\/scisignal.adv4112\" target=\"_blank\" rel=\"noopener\">Read the Science Signaling paper<span class=\"screen-reader-text\"> (opens in a new tab)<\/span><\/a><br \/>\n      <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41218104\/\" target=\"_blank\" rel=\"noopener\">View in PubMed<span class=\"screen-reader-text\"> (opens in a new tab)<\/span><\/a>\n    <\/p>\n<\/p><\/div>\n<figure class=\"cp-car-finding\" aria-labelledby=\"cp-car-finding-caption\">\n<div class=\"cp-car-finding-scroll\">\n      <img decoding=\"async\" src=\"https:\/\/cellpathway.com\/wp-content\/themes\/artsalomon\/images\/csf1r-car-target-outcomes.svg?v=20260804c\" width=\"960\" height=\"390\" loading=\"lazy\" alt=\"Diagram comparing CSF1R-CAR target-cell outcomes across effector-to-target ratios. A complete text description follows.\">\n    <\/div><figcaption id=\"cp-car-finding-caption\"><strong>Conceptual summary of the published result.<\/strong> CSF1R-CAR T cells promote THP-1 target-cell growth at low effector-to-target ratios and target-cell lysis at high ratios.<\/figcaption><\/figure>\n<details id=\"cp-car-text-description\" class=\"cp-car-text-description\">\n<summary>Text description of CAR target-cell diagram<\/summary>\n<div class=\"cp-car-text-description-body\">\n<p><strong>Overall structure:<\/strong> The diagram reads from left to right as the number of CSF1R-CAR T cells per target cell increases. Rose circles represent CAR T cells, gold circles represent CSF1R-positive target cells, and an arrow along the bottom shows the increasing effector-to-target ratio.<\/p>\n<dl>\n<dt>Target-rich contact, low effector-to-target ratio<\/dt>\n<dd>A CAR T cell contacts a target cell and activates CSF1R phosphotyrosine signaling. Under these target-rich conditions, the observed outcome is target-cell growth.<\/dd>\n<dt>The target is not passive<\/dt>\n<dd>Cell-of-origin phosphoproteomics separates signals from the two cell types. Target-cell signaling requires the kinase activity of CSF1R. T-cell Lck activity and actin polymerization are not required for this response.<\/dd>\n<dt>Effector-rich contact, high effector-to-target ratio<\/dt>\n<dd>Multiple CAR T cells contact a target cell. Under these effector-rich conditions, the observed outcome shifts to target-cell lysis.<\/dd>\n<\/dl><\/div>\n<\/details>\n<div class=\"cp-car-song\" role=\"group\" aria-labelledby=\"cp-car-song-title\">\n<div class=\"cp-car-song-intro\">\n      <span class=\"cp-car-song-icon\" aria-hidden=\"true\">&#9835;<\/span><\/p>\n<div>\n<h3 id=\"cp-car-song-title\">CSF1R Low Ratio<\/h3>\n<p>A musical take on the target-cell response.<\/p>\n<\/p><\/div>\n<\/p><\/div>\n<p>    <audio controls preload=\"none\" aria-label=\"Play CSF1R Low Ratio\"><source src=\"https:\/\/cellpathway.com\/wp-content\/uploads\/2026\/08\/csf1r-low-ratio.mp3?v=20260804\" type=\"audio\/mpeg\">Your browser does not support the audio player. <a href=\"https:\/\/cellpathway.com\/wp-content\/uploads\/2026\/08\/csf1r-low-ratio.mp3?v=20260804\">Download CSF1R Low Ratio<\/a>.<\/audio><\/p>\n<p class=\"cp-car-song-credit\">Music created with Suno.com.<\/p>\n<\/p><\/div>\n<\/section>\n","protected":false},"excerpt":{"rendered":"<p>Welcome to the Salomon Laboratory Decoding how molecular networks shape immune-cell responses. Immune cells must decide when to respond, how strongly to act, and when to stop. The Salomon Laboratory studies the molecular messages that guide those choices, both in natural immune responses and in engineered cell therapies. By combining advanced mass spectrometry, biochemistry, and [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"open","template":"","meta":{"footnotes":""},"class_list":["post-2","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/cellpathway.com\/index.php?rest_route=\/wp\/v2\/pages\/2","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cellpathway.com\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/cellpathway.com\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/cellpathway.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cellpathway.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2"}],"version-history":[{"count":130,"href":"https:\/\/cellpathway.com\/index.php?rest_route=\/wp\/v2\/pages\/2\/revisions"}],"predecessor-version":[{"id":1141,"href":"https:\/\/cellpathway.com\/index.php?rest_route=\/wp\/v2\/pages\/2\/revisions\/1141"}],"wp:attachment":[{"href":"https:\/\/cellpathway.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}